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Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation
Joint Authors
Ronco, Claudio
Corsi Romanelli, Massimiliano M.
de Cal, Massimo
Vianello, Elena
Corradi, Valentina
Scalzotto, Elisa
Dozio, Elena
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression.
Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D).
Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure.
Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients.
The levels of sRAGE, cFGF-23, BNP, and proinflammatory markers were over the ranges of normality in both DM and non-DM groups.
Only GA and sRAGE levels were increased in DM compared to non-DM patients.
Plasma levels of sRAGE and CRP were the only independent predictors of BNP concentration.
In conclusion, in DM CKD-G5D patients, sRAGE appeared to be a marker of cardiac remodeling.
Indeed, its increase could be a potential protective mechanism against the increased risk of cardiovascular complications related to AGEs and inflammation.
The causal relationship between sRAGE and cardiovascular risk in these patients needs to be further confirmed by mechanistic studies.
American Psychological Association (APA)
Dozio, Elena& Corradi, Valentina& Vianello, Elena& Scalzotto, Elisa& de Cal, Massimo& Corsi Romanelli, Massimiliano M.…[et al.]. 2017. Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188851
Modern Language Association (MLA)
Dozio, Elena…[et al.]. Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188851
American Medical Association (AMA)
Dozio, Elena& Corradi, Valentina& Vianello, Elena& Scalzotto, Elisa& de Cal, Massimo& Corsi Romanelli, Massimiliano M.…[et al.]. Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188851