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Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi
Joint Authors
Parente-Rocha, Juliana Alves
Bailão, Alexandre Melo
Amaral, André Correa
Taborda, Carlos Pelleschi
Paccez, Juliano Domiraci
Borges, Clayton Luiz
Pereira, Maristela
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Diseases caused by fungi can occur in healthy people, but immunocompromised patients are the major risk group for invasive fungal infections.
Cases of fungal resistance and the difficulty of treatment make fungal infections a public health problem.
This review explores mechanisms used by fungi to promote fungal resistance, such as the mutation or overexpression of drug targets, efflux and degradation systems, and pleiotropic drug responses.
Alternative novel drug targets have been investigated; these include metabolic routes used by fungi during infection, such as trehalose and amino acid metabolism and mitochondrial proteins.
An overview of new antifungal agents, including nanostructured antifungals, as well as of repositioning approaches is discussed.
Studies focusing on the development of vaccines against antifungal diseases have increased in recent years, as these strategies can be applied in combination with antifungal therapy to prevent posttreatment sequelae.
Studies focused on the development of a pan-fungal vaccine and antifungal drugs can improve the treatment of immunocompromised patients and reduce treatment costs.
American Psychological Association (APA)
Parente-Rocha, Juliana Alves& Bailão, Alexandre Melo& Amaral, André Correa& Taborda, Carlos Pelleschi& Paccez, Juliano Domiraci& Borges, Clayton Luiz…[et al.]. 2017. Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188855
Modern Language Association (MLA)
Parente-Rocha, Juliana Alves…[et al.]. Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188855
American Medical Association (AMA)
Parente-Rocha, Juliana Alves& Bailão, Alexandre Melo& Amaral, André Correa& Taborda, Carlos Pelleschi& Paccez, Juliano Domiraci& Borges, Clayton Luiz…[et al.]. Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188855