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Differential MicroRNA-Signatures in Thyroid Cancer Subtypes
Joint Authors
Santiago, Krystal
Chen Wongworawat, Yan
Khan, Salma
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Thyroid cancer is one of the most common endocrine cancers, with an increasing trend in the last few decades.
Although papillary thyroid cancer is the most frequent subtype compared with follicular or anaplastic thyroid cancer, it can dedifferentiate to a more aggressive phenotype, and the recurrence rate is high.
The cells of follicular adenomas and follicular carcinomas appear identical in cytology, making the preoperative diagnosis difficult.
On the other hand, anaplastic thyroid cancer poses a significant clinical challenge due to its aggressive nature with no effective therapeutic options.
In the past several years, the roles of genetic alterations of thyroid tumors have been documented, with a remarkable correlation between genotype and phenotype, indicating that distinct molecular changes are associated with a multistep tumorigenic process.
Besides mRNA expression profiles, small noncoding microRNA (miRNA) expression also showed critical functions for cell differentiation, proliferation, angiogenesis, and resistance to apoptosis and finally activating invasion and metastasis in cancer.
Several high-throughput sequencing studies demonstrate that miRNA expression signatures contribute clinically relevant information including types of thyroid cancer, tumor grade, and prognosis.
This review summarizes recent findings on miRNA signatures in thyroid cancer subtypes.
American Psychological Association (APA)
Santiago, Krystal& Chen Wongworawat, Yan& Khan, Salma. 2020. Differential MicroRNA-Signatures in Thyroid Cancer Subtypes. Journal of Oncology،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1188864
Modern Language Association (MLA)
Santiago, Krystal…[et al.]. Differential MicroRNA-Signatures in Thyroid Cancer Subtypes. Journal of Oncology No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1188864
American Medical Association (AMA)
Santiago, Krystal& Chen Wongworawat, Yan& Khan, Salma. Differential MicroRNA-Signatures in Thyroid Cancer Subtypes. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1188864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188864