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HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer
Joint Authors
Kuang, Tiantao
Fang, Yuan
Han, Xu
Li, Jianang
Lou, Wenhui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To discover the correlated gene with HEATR1 in regulating chemoresistance of gemcitabine.
Methods.
Gene chip analysis was performed to find out differential genes between HEATR1-KD and control groups.
The top 20 genes were subjected to high-content screening, and functional assay was implemented.
Gene expression profiling was carried out to find the downstream target.
Immunohistochemistry and survival analysis were performed.
Results.
ZNF185 fold change (4.5285) was the most significant between the HEATR1-KD and control groups.
Knocking down ZNF185 could promote the chemosensitivity, apoptosis, and proliferative inhibition, with SMAD4 significantly upregulated.
Patients with high HEATR1 and SMAD4 or low ZNF185 exhibited better survival.
Conclusion.
HEATR1, ZNF185, and SMAD4 could affect the chemosensitivity of gemcitabine and may be the indicators of gemcitabine selection in the chemotherapy of pancreatic cancer.
American Psychological Association (APA)
Fang, Yuan& Han, Xu& Li, Jianang& Kuang, Tiantao& Lou, Wenhui. 2020. HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188893
Modern Language Association (MLA)
Fang, Yuan…[et al.]. HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer. Journal of Oncology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1188893
American Medical Association (AMA)
Fang, Yuan& Han, Xu& Li, Jianang& Kuang, Tiantao& Lou, Wenhui. HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188893