miR-200b200a429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5
Joint Authors
Guan, Wei
Cui, Huiling
Huang, Ping
Chun, Wan Joo
Lee, Jin-Won
Kim, Heasung
Zou, Hua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ovarian cancer is the second most common gynaecological malignancy, and microRNAs (miRNAs) play important role in the cancer development.
Here, we found that the level of miR-200b/200a/429 was significantly increased in serum and tumor tissues of patients with stage-I ovarian cancer.
Consistent with these results, we detected increased expression levels of miR-200b/200a/429 in ovarian cancer cell lines compared with the human nontumorigenic ovarian epithelial cell line T80.
The overexpression of miR-200b/200a/429 in T80 cells stimulated proliferation and caused their growth in soft agar and tumor formation in nude mice.
Furthermore, we determined that miR-200b/200a/429 targets inhibitor of growth family 5 (ING5) and that the overexpression of ING5 can block miR-200b/200a/429-induced T80 cell transformation and tumorigenesis.
Our findings suggest that miR-200b/200a/429 may be a useful biomarker for the early detection of ovarian cancer and that miR-200b/200a/429 significantly contributes to ovarian cancer development through ING5.
American Psychological Association (APA)
Guan, Wei& Cui, Huiling& Huang, Ping& Chun, Wan Joo& Lee, Jin-Won& Kim, Heasung…[et al.]. 2020. miR-200b200a429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5. Journal of Oncology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188899
Modern Language Association (MLA)
Guan, Wei…[et al.]. miR-200b200a429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5. Journal of Oncology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1188899
American Medical Association (AMA)
Guan, Wei& Cui, Huiling& Huang, Ping& Chun, Wan Joo& Lee, Jin-Won& Kim, Heasung…[et al.]. miR-200b200a429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188899