Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer
Joint Authors
Senchukova, Marina A.
Makarova, Elena V.
Shurygina, Elena I.
Volchenko, Nadezhda N.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-12
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The determination of factors associated with progression of cervical cancer is important, both for a recurrence risk assessment and for determining optimal treatment tactics.
Previously, we showed the prognostic value of different types of tumor microvessels (MVs) in gastric and breast cancer.
The object of this research was to study the morphology and clinical significance of different tumor microvessels in early cervical cancer.
A total of 65 archived paraffin blocks of patients with I-IIA stages of squamous cervical cancer were investigated.
Samples were stained with Mayer hematoxylin and immunohistochemically using antibodies to CD34, podoplanin, HIF-1a, and Snail.
The eight types of tumor MVs differed in morphology were identified.
It was established that only the dilated capillaries (DСs) with weak expression of CD34, the contact type DCs, the capillaries in tumor solid component, and the lymphatic vessels in the lymphoid and polymorphic cell infiltrates of tumor stroma are associated with clinical and pathological characteristics of early cervical cancer.
Preliminary results also suggest that a combination of fragmentation in tumor solid component and the contact type DCs may predict a recurrence of early cervical cancer.
Given the small number of cervical cancer recurrences, the predictive significance of the described markers requires a more thorough examination.
American Psychological Association (APA)
Senchukova, Marina A.& Makarova, Elena V.& Shurygina, Elena I.& Volchenko, Nadezhda N.. 2020. Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1188916
Modern Language Association (MLA)
Senchukova, Marina A.…[et al.]. Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer. Journal of Oncology No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1188916
American Medical Association (AMA)
Senchukova, Marina A.& Makarova, Elena V.& Shurygina, Elena I.& Volchenko, Nadezhda N.. Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1188916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188916