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Italian Men Tested for BRCA12 Mutation: Psychological Distress during 6-Month Follow-Up
Joint Authors
Pellini, F.
Mirandola, S.
Granuzzo, E.
Urbani, S.
Piccinni Leopardi, G.
Pollini, G. P.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Male breast cancer (MBC) is a rare disease, whose main risk factor is genetic vulnerability.
Despite care of men with MBC is modeled on care of women, men’s experiences with the disease and concerns related to the status of genetic mutation carrier are unique.
So far, little is known concerning the psychological impact in BRCA1/2 testing, especially with regard to specific subset of individuals, such as male subjects and the elderly.
Methods.
We assessed self-reported anxiety and depression levels in 26 male subjects presenting at Unit of Breast Surgery in Breast Unit of AOUI Verona (MBC patients, n = 7; high-risk unaffected subjects, n = 19).
We specifically examined the scores obtained by these subjects in the HADS questionnaire administered before and 6 months after the genetic testing for BRCA gene mutations.
Results.
Among the 17 unaffected men tested, 7 (41%) received a positive test (either BRCA1 or BRCA2 pathogenic variant) and 10 (59%) a negative test.
Of the 9 MBC patients tested, only one subject received a positive test result.
No significant differences were observed in mean scores, mean change from baseline to follow-up, either for those with T+ or T− test results.
Discussion.
Genetic testing for BRCA1/2 mutation was not associated in our sample with increased level of psychological distress as measured with HADS in a short-term evaluation.
American Psychological Association (APA)
Pellini, F.& Mirandola, S.& Granuzzo, E.& Urbani, S.& Piccinni Leopardi, G.& Pollini, G. P.. 2020. Italian Men Tested for BRCA12 Mutation: Psychological Distress during 6-Month Follow-Up. Journal of Oncology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1188932
Modern Language Association (MLA)
Pellini, F.…[et al.]. Italian Men Tested for BRCA12 Mutation: Psychological Distress during 6-Month Follow-Up. Journal of Oncology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1188932
American Medical Association (AMA)
Pellini, F.& Mirandola, S.& Granuzzo, E.& Urbani, S.& Piccinni Leopardi, G.& Pollini, G. P.. Italian Men Tested for BRCA12 Mutation: Psychological Distress during 6-Month Follow-Up. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1188932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188932