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Association of Genetic Polymorphisms in TNFRSF11 with the Progression of Genetic Susceptibility to Gastric Cancer
Joint Authors
Gu, Xu-yu
Dai, Zhe
Pan, Hui-wen
Zhang, Heng
Fan, Yu
Zou, Chen
Gao, Zhenjun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the relationship between polymorphism of TNFRSF11 gene rs9533156 and rs2277438 and susceptibility to gastric cancer.
Methods.
A case-control study was conducted to select 577 cases of primary gastric cancer and 678 cases of normal control.
We extracted whole blood genomic DNA and amplified the target gene fragment by PCR.
The genotyping and allele were tested through the snapshot method.
Results.
In this case-control study, we observed that there was a difference in the genotype distribution of TNFRSF11 gene rs9533156 between the case group and the control group.
The frequency distribution of TC heterozygous mutation in the case group was higher than that in the control group.
The smoking rate in the case group (34.49%) was higher than that in the control group (27.29%), and the difference in frequency distribution between the two groups was statistically significant (P=0.006).
Our findings suggest that TNFRSF11 rs9533156 is associated with susceptibility to GC, which is more evident among elderly patients (>62 years), nonsmokers, and patients who do not consume alcohol.
The analysis of the relationship between the TNFSF11 gene rs9533156 site variant and clinical factors of gastric cancer showed that, compared with the tumor size <2 cm group, patients with tumor size ≥2 cm and whom carrying rs9533156 site mutations had a higher frequency distribution, and the difference was statistically significant (P=0.022).
Compared with the nonhyperglycemic group, the frequency distribution of patients with rs9533156 site mutations in the diabetes group was higher, and the difference was statistically significant (P<0.001).
Conclusion.
This study shows that there is a correlation between smoking and the occurrence of gastric cancer.
Based on our research, the functional SNP TNFRSF11 TC genotype may be an indicator of individual susceptibility to GC.
The mutation at rs9533156 may be related to the size of gastric cancer.
The mutation rate of rs9533156 of TNFSF11 gene is higher in diabetic gastric cancer patients.
American Psychological Association (APA)
Fan, Yu& Gu, Xu-yu& Pan, Hui-wen& Dai, Zhe& Zou, Chen& Gao, Zhenjun…[et al.]. 2020. Association of Genetic Polymorphisms in TNFRSF11 with the Progression of Genetic Susceptibility to Gastric Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1188937
Modern Language Association (MLA)
Fan, Yu…[et al.]. Association of Genetic Polymorphisms in TNFRSF11 with the Progression of Genetic Susceptibility to Gastric Cancer. Journal of Oncology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1188937
American Medical Association (AMA)
Fan, Yu& Gu, Xu-yu& Pan, Hui-wen& Dai, Zhe& Zou, Chen& Gao, Zhenjun…[et al.]. Association of Genetic Polymorphisms in TNFRSF11 with the Progression of Genetic Susceptibility to Gastric Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1188937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188937