BRCA Mutations in Prostate Cancer: Prognostic and Predictive Implications
Joint Authors
Messina, Carlo
Cattrini, Carlo
Soldato, Davide
Vallome, Giacomo
Caffo, Orazio
Boccardo, Francesco
Zanardi, Elisa
Olmos, David
Castro, Elena
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite chemotherapy and novel androgen-receptor signalling inhibitors (ARSi) have been approved during the last decades, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with poor clinical outcomes.
Several studies found that germline or acquired DNA damage repair (DDR) defects affect a high percentage of mCRPC patients.
Among DDR defects, BRCA mutations show relevant clinical implications.
BRCA mutations are associated with adverse clinical features in primary tumors and with poor outcomes in patients with mCRPC.
In addition, BRCA mutations predict good response to poly-ADP ribose polymerase (PARP) inhibitors, such as olaparib, rucaparib, and niraparib.
However, concerns still remain on the role of extensive mutational testing in prostate cancer patients, given the implications for patients and for their progeny.
The present comprehensive review attempts to provide an overview of BRCA mutations in prostate cancer, focusing on their prognostic and predictive roles.
American Psychological Association (APA)
Messina, Carlo& Cattrini, Carlo& Soldato, Davide& Vallome, Giacomo& Caffo, Orazio& Castro, Elena…[et al.]. 2020. BRCA Mutations in Prostate Cancer: Prognostic and Predictive Implications. Journal of Oncology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1188970
Modern Language Association (MLA)
Messina, Carlo…[et al.]. BRCA Mutations in Prostate Cancer: Prognostic and Predictive Implications. Journal of Oncology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1188970
American Medical Association (AMA)
Messina, Carlo& Cattrini, Carlo& Soldato, Davide& Vallome, Giacomo& Caffo, Orazio& Castro, Elena…[et al.]. BRCA Mutations in Prostate Cancer: Prognostic and Predictive Implications. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1188970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188970