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ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility
Joint Authors
Gao, Zhi-Gang
Yang, Yong
Han, Xiao-Feng
Wang, Yun-Lei
Wang, Zhen-Jun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Colorectal cancer (CRC) is the 5th leading cancer in China.
Alcohol consumption has been reported to be one of the risk factors of CRC.
However, it remains unclear whether genetic variants of alcohol metabolic genes are associated with CRC risk.
In this study, we tested the coding variants in the alcohol metabolic genes and the risk of CRC, by using 485 cases and 516 controls.
A total of 16 germline coding variants in 10 alcohol metabolic genes were genotyped.
We identified that rs3741178 in ALDH3B2 was significantly associated with CRC risk with odds ratio being 2.13 (95% CI: 1.24–3.68, P=0.0064).
Further functional annotation suggested that this variant may damage the protein function of ALDH3B2.
Our results suggested that ALDH3B2 in the alcohol metabolism pathway contributed to the development of CRC, which may contribute to the prevention of this disease in the future.
American Psychological Association (APA)
Gao, Zhi-Gang& Yang, Yong& Han, Xiao-Feng& Wang, Yun-Lei& Wang, Zhen-Jun. 2020. ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility. Journal of Oncology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1188975
Modern Language Association (MLA)
Gao, Zhi-Gang…[et al.]. ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility. Journal of Oncology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1188975
American Medical Association (AMA)
Gao, Zhi-Gang& Yang, Yong& Han, Xiao-Feng& Wang, Yun-Lei& Wang, Zhen-Jun. ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1188975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188975