Physical Properties of Nanoparticles That Result in Improved Cancer Targeting
Joint Authors
Zein, Randa
Sharrouf, Wissam
Selting, Kim
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target, and drug penetration into tumors is limited by abnormal vasculature and high interstitial pressure.
Chemotherapy is the most common systemic treatment for cancer but can cause undesirable adverse effects, including toxicity to the bone marrow and gastrointestinal system.
Therefore, nanotechnology-based drug delivery systems have been developed to reduce the adverse effects of traditional chemotherapy by enhancing the penetration and selective drug retention in tumor tissues.
A thorough knowledge of the physical properties (e.g., size, surface charge, shape, and mechanical strength) and chemical attributes of nanoparticles is crucial to facilitate the application of nanotechnology to biomedical applications.
This review provides a summary of how the attributes of nanoparticles can be exploited to improve therapeutic efficacy.
An ideal nanoparticle is proposed at the end of this review in order to guide future development of nanoparticles for improved drug targeting in vivo.
American Psychological Association (APA)
Zein, Randa& Sharrouf, Wissam& Selting, Kim. 2020. Physical Properties of Nanoparticles That Result in Improved Cancer Targeting. Journal of Oncology،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1188977
Modern Language Association (MLA)
Zein, Randa…[et al.]. Physical Properties of Nanoparticles That Result in Improved Cancer Targeting. Journal of Oncology No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1188977
American Medical Association (AMA)
Zein, Randa& Sharrouf, Wissam& Selting, Kim. Physical Properties of Nanoparticles That Result in Improved Cancer Targeting. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1188977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188977