Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIVAIDS
Joint Authors
Wang, Yiying
Wang, Yue
Zheng, Wenxin
Wang, Yan
Gaisa, Michael M.
Sigel, Keith
Liu, Yuxin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
People living with HIV/AIDS (PLWHA) have an increased incidence of anal squamous cell carcinoma.
Since high-risk human papillomavirus (hrHPV) is the primary cause, hrHPV DNA testing may play an important role in anal cancer screening.
This study aims to determine the negative predictive value (NPV) of hrHPV testing in PLWHA as well as factors that may lead to false-negative results.
Methods.
Anal swabs were collected for cytology and Cobas® 4800 HPV test for 14 hrHPV types.
Patients underwent concomitant high-resolution anoscopy (HRA) examination and biopsy.
High-grade squamous intraepithelial lesions (HSIL, synonymous with anal intraepithelial neoplasia AIN2 and 3) detected in Cobas-negative patients were genotyped for 22 HPV types using BioPerfectus Multiplex Real-time PCR.
Results.
156 PLWHA tested negative for hrHPV on anal swab samples (i.e., Cobas-negative).
HRA-guided biopsy detected HSIL/AIN3 in 13 patients (8%, NPV 92%), HSIL/AIN2 in 5 patients (3%), low-grade squamous intraepithelial lesions in 82 (LSIL, 53%), or benign findings in 56 (36%).
No cancer was found.
The HSIL group was similar to the LSIL/benign group regarding age, gender, race/ethnicity, clinical HIV parameters, cytological diagnoses, history of receptive anal sex, and smoking (p≥0.02).
Genotyping HSIL tissue derived from Cobas-negative patients revealed hrHPV (n=7), possibly carcinogenic HPV53, 67, 73, 82 (n=12), or absence of hrHPV (n=4).
Conclusions.
In this series, anal hrHPV DNA testing offered 92% NPV for PLWHA; in other words, a 8% risk of occult precancer remains for those who test hrHPV negative on anal swab samples.
American Psychological Association (APA)
Wang, Yiying& Wang, Yan& Gaisa, Michael M.& Sigel, Keith& Zheng, Wenxin& Liu, Yuxin…[et al.]. 2020. Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIVAIDS. Journal of Oncology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189025
Modern Language Association (MLA)
Wang, Yiying…[et al.]. Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIVAIDS. Journal of Oncology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189025
American Medical Association (AMA)
Wang, Yiying& Wang, Yan& Gaisa, Michael M.& Sigel, Keith& Zheng, Wenxin& Liu, Yuxin…[et al.]. Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIVAIDS. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189025