Efficacy of Panobinostat for the Treatment of Multiple Myeloma

Joint Authors

Gavriatopoulou, Maria
Eleutherakis-Papaiakovou, Evangelos
Kanellias, Nikolaos
Terpos, Evangelos
Kastritis, Efstathios
Dimopoulos, Meletios-A.

Source

Journal of Oncology

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-01-13

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases
Medicine

Abstract EN

Panobinostat represents a potent oral nonselective pan-histone deacetylase inhibitor (HDAC) with activity in myeloma patients.

It has been approved by the FDA and EMA in combination with bortezomib and dexamethasone for the treatment of multiple myeloma, in patients who have received at least two prior regimens, including bortezomib and an immunomodulatory agent.

In order to further explore its clinical potential, it is evaluated in different combinations in relapsed/refractory and newly diagnosed multiple myeloma.

This review focuses on available data about panobinostat’s pharmacology and its role in clinical practice.

This review will reveal panobinostat’s efficacy as antimyeloma treatment, describing drug evolution from preclinical experimental administration to administration in phase III trials, which established its role in current clinical practice.

Based on the latest data, we will present its mechanism of action, its efficacy, and most important issues regarding its toxicity profile.

We will further try to shed light on its role in current and future therapeutic landscape of myeloma patients.

Panobinostat retains its role in therapy of multiple myeloma because of its manageable toxicity profile and its efficacy, mainly in heavily pretreated multiple myeloma patients.

These characteristics make it valuable also for novel regimens in combination with second-generation proteasome inhibitors, IMiDs, and monoclonal antibodies.

Results of ongoing trials are expected to shed light on drug introduction in different therapeutic combinations or even at an earlier level of disease course.

American Psychological Association (APA)

Eleutherakis-Papaiakovou, Evangelos& Kanellias, Nikolaos& Kastritis, Efstathios& Gavriatopoulou, Maria& Terpos, Evangelos& Dimopoulos, Meletios-A.. 2020. Efficacy of Panobinostat for the Treatment of Multiple Myeloma. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189066

Modern Language Association (MLA)

Eleutherakis-Papaiakovou, Evangelos…[et al.]. Efficacy of Panobinostat for the Treatment of Multiple Myeloma. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189066

American Medical Association (AMA)

Eleutherakis-Papaiakovou, Evangelos& Kanellias, Nikolaos& Kastritis, Efstathios& Gavriatopoulou, Maria& Terpos, Evangelos& Dimopoulos, Meletios-A.. Efficacy of Panobinostat for the Treatment of Multiple Myeloma. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189066

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1189066