Exosomal Long Noncoding RNAs: Insights into Emerging Diagnostic and Therapeutic Applications in Lung Cancer
Joint Authors
Sahebkar, Amirhossein
Karimzadeh, Mohammad Reza
Seyedtaghia, Mohammad Reza
Soudyab, Mohammad
Nezamnia, Maria
Kidde, Jason
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is the most common cause of cancer-related deaths worldwide.
Annually, millions of people die from lung cancer because of late detection and ineffective therapies.
Recently, exosomes have been introduced as new therapeutic players with the potential to improve upon current diagnostic and treatment options.
Exosomes are small membranous vesicles produced during endosomal merging.
This allows for cell packaging of nucleic acids, proteins, and lipids and transfer to adjacent or distant cells.
While exosomes are a part of normal intercellular signaling, they also allow malignant cells to transfer oncogenic material leading to tumor spread and metastasis.
Exosomes are an interesting field of discovery for biomarkers and therapeutic targets.
Among exosomal materials, lncRNAs have priority; lncRNAs are a class of noncoding RNAs longer than 200 base pairs.
In the case of cancer, primary interest regards their oncogene and tumor suppressor functions.
In this review, the advantages of exosomal lncRNAs as biomarkers and therapeutic targets will be discussed in addition to reviewing studies of their application in lung cancer.
American Psychological Association (APA)
Karimzadeh, Mohammad Reza& Seyedtaghia, Mohammad Reza& Soudyab, Mohammad& Nezamnia, Maria& Kidde, Jason& Sahebkar, Amirhossein. 2020. Exosomal Long Noncoding RNAs: Insights into Emerging Diagnostic and Therapeutic Applications in Lung Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189089
Modern Language Association (MLA)
Karimzadeh, Mohammad Reza…[et al.]. Exosomal Long Noncoding RNAs: Insights into Emerging Diagnostic and Therapeutic Applications in Lung Cancer. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189089
American Medical Association (AMA)
Karimzadeh, Mohammad Reza& Seyedtaghia, Mohammad Reza& Soudyab, Mohammad& Nezamnia, Maria& Kidde, Jason& Sahebkar, Amirhossein. Exosomal Long Noncoding RNAs: Insights into Emerging Diagnostic and Therapeutic Applications in Lung Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189089