Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
Joint Authors
Afshari, Amir R.
Mollazadeh, Hamid
Sahebkar, Amirhossein
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features.
Its invasiveness is responsible for the high recurrence even after maximal surgical interventions.
Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity.
In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology.
Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM.
The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.
American Psychological Association (APA)
Afshari, Amir R.& Mollazadeh, Hamid& Sahebkar, Amirhossein. 2020. Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189118
Modern Language Association (MLA)
Afshari, Amir R.…[et al.]. Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189118
American Medical Association (AMA)
Afshari, Amir R.& Mollazadeh, Hamid& Sahebkar, Amirhossein. Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189118