Integrative Analysis Reveals the Landscape of Hypoxia-Inducible Factor (HIF) Family Genes in Pan-Cancer
Joint Authors
Yang, Qian-Kun
Wang, Xue-Xin
Ni, Ni
Wang, Yang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inside the cancer microenvironment, reduced O2 concentration, termed as hypoxia, is a common phenotype and leads to cancer progression.
However, little is known about how and when those HIF members are dysregulated in distinct cancers.
Here, by integrating a full range of data of thousands of patients, we comprehensively analyzed the genetics, epigenetics, and transcriptomic level of HIF genes and further defined pathways triggered by disrupted hypoxia-inducible factors.
We reveal the expression landscape of HIF family genes and further demonstrate that copy number variations underlie such dysregulation.
Further analysis indicates that HIF genes associate with cancer hallmarks such as cell cycle and DNA damage response.
Drug resistance analysis showed that HIF globally impacts drug effectiveness such as docetaxel.
In summary, the overall analysis reveals the landscape of HIF genes in pan-cancer and may assist mechanism research about hypoxia.
American Psychological Association (APA)
Yang, Qian-Kun& Wang, Xue-Xin& Wang, Yang& Ni, Ni. 2020. Integrative Analysis Reveals the Landscape of Hypoxia-Inducible Factor (HIF) Family Genes in Pan-Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189148
Modern Language Association (MLA)
Yang, Qian-Kun…[et al.]. Integrative Analysis Reveals the Landscape of Hypoxia-Inducible Factor (HIF) Family Genes in Pan-Cancer. Journal of Oncology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189148
American Medical Association (AMA)
Yang, Qian-Kun& Wang, Xue-Xin& Wang, Yang& Ni, Ni. Integrative Analysis Reveals the Landscape of Hypoxia-Inducible Factor (HIF) Family Genes in Pan-Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189148