Identification of Risk Factors Associated with Axillary Lymph Node Metastasis for Sentinel Lymph Node-Positive Breast Cancer Patients

Joint Authors

Wang, Xicheng
Wen, Ge
Lin, Xiao
Huang, Xiaobo
He, Zhen
Lan, Xiaowen
Tan, Yuting
Yang, Fan

Source

Journal of Oncology

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-29

Country of Publication

Egypt

No. of Pages

9

Main Topic

Diseases
Medicine

Abstract EN

Objective.

This study aimed to identify clinicopathological factors related to the extent of axillary lymph node (ALN) involvement in early-stage BC patients with positive sentinel lymph nodes (SLNs).

Methods.

This was a retrospective analysis of 566 patients in cT1-2N0M0 with 1-2 positive SLNs that underwent axillary lymph node dissection (ALND) at Sun Yat-Sen Memorial Hospital.

The clinical and pathologic data from these patients were analyzed.

Results.

Of these 566 patients, 235 (41.5%) exhibited NSLN metastases.

Multivariate analysis revealed that the number of positive SLNs (odds ratio (OR) = 1.511; P=0.038), the ratio of metastatic/dissected SLNs (SLN metastasis rate) (OR = 2.124; P<0.001), and lymphovascular invasion (LVI) (OR = 1.503; P=0.022) were all independent predictors of NSLN metastasis.

Patients with 0, 1, 2, or 3 of these risk factors exhibited NSLN metastases in 29.3%, 35.7%, 50.8%, and 68.3% of cases, respectively.

We additionally found that the number of positive SLNs (OR = 3.582; P<0.001), SLN metastasis rate (OR = 2.505; P=0.001), LVI (OR = 2.010; P=0.004), and HER2 overexpression (OR = 1.774; P=0.034) were all independent predictors of N2 disease.

When individuals had 0, 1, 2, 3, or 4 of these risk factors, they had four or more involved ALNs in 5.2%, 10.8%, 21.1%, 37.5%, and 70.6% of cases, respectively.

Conclusion.

These results suggest that the number of positive SLNs, the SLN metastasis rate, and LVI are all significant predictors of ALN status in BC patients that have 1-2 positive SLNs and that have undergone ALND.

In addition, HER2 overexpression was a significant predictor of N2 disease.

American Psychological Association (APA)

He, Zhen& Lan, Xiaowen& Tan, Yuting& Lin, Xiao& Wen, Ge& Wang, Xicheng…[et al.]. 2020. Identification of Risk Factors Associated with Axillary Lymph Node Metastasis for Sentinel Lymph Node-Positive Breast Cancer Patients. Journal of Oncology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189151

Modern Language Association (MLA)

He, Zhen…[et al.]. Identification of Risk Factors Associated with Axillary Lymph Node Metastasis for Sentinel Lymph Node-Positive Breast Cancer Patients. Journal of Oncology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189151

American Medical Association (AMA)

He, Zhen& Lan, Xiaowen& Tan, Yuting& Lin, Xiao& Wen, Ge& Wang, Xicheng…[et al.]. Identification of Risk Factors Associated with Axillary Lymph Node Metastasis for Sentinel Lymph Node-Positive Breast Cancer Patients. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189151

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1189151