Association of Tumor Size with Risk of Lymph Node Metastasis in Clear Cell Renal Cell Carcinoma: A Population-Based Study
Joint Authors
Zhi, Yunlai
Li, Xiao
Qi, Feng
Hu, Xin
Xu, Wenbo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this article was to explore the association of tumor size with lymph node metastases (LNM) risk in patients with clear cell renal cell carcinoma (ccRCC).
Based on the Surveillance, Epidemiology, and End Result (SEER) database, patients diagnosed with ccRCC from 1988 to 2015 were included in this study.
For each patient, personal characteristics, clinicopathological data, and survival outcomes were, respectively, collected.
Subsequently, the odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to investigate the potential risk factors for LNM in ccRCC.
Finally, Kaplan-Meier (KM) survival plots of overall survival (OS) and ccRCC-specific survival (CSS) were evaluated on the basis of different tumor sizes.
A total of 8,292 patients were finally enrolled in the study, 1,170 of whom (14.11%) had LNM.
According to the heatmap, we could intuitively interpret that larger tumor size was related to an increased risk of LNM obviously.
The risk of LNM was evidently greater for larger tumor size (4-7 cm: OR = 2.415, 95% CI = 1.708–3.415; 7–10 cm: OR = 3.746, 95% CI = 2.677–5.242; and >10 cm: OR = 4.617, 95% CI = 3.302–6.457) compared with smaller tumor size (≤4 cm).
According to the KM survival plots of OS and CSS, we observed a gradual decline in survival with increasing tumor size, while the smallest tumor size had the best survival outcomes.
These results indicated the positive relationship of tumor size with risk of LNM in ccRCC.
And we also noticed continual decrease survival rates of OS and CSS with increasing tumor size.
American Psychological Association (APA)
Zhi, Yunlai& Li, Xiao& Qi, Feng& Hu, Xin& Xu, Wenbo. 2020. Association of Tumor Size with Risk of Lymph Node Metastasis in Clear Cell Renal Cell Carcinoma: A Population-Based Study. Journal of Oncology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189154
Modern Language Association (MLA)
Zhi, Yunlai…[et al.]. Association of Tumor Size with Risk of Lymph Node Metastasis in Clear Cell Renal Cell Carcinoma: A Population-Based Study. Journal of Oncology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189154
American Medical Association (AMA)
Zhi, Yunlai& Li, Xiao& Qi, Feng& Hu, Xin& Xu, Wenbo. Association of Tumor Size with Risk of Lymph Node Metastasis in Clear Cell Renal Cell Carcinoma: A Population-Based Study. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189154