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Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377
Joint Authors
Fan, Yu
Fang, Na
Shi, Yijun
Long, Tao
Shu, Yongqian
Zhou, Jianwei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Circular RNA (circRNA) is an endogenous noncoding RNA.
Accumulative investigations have confirmed that circRNAs play a vital role in carcinogenesis and tumor progression.
Herein, we examined the expression and mechanism of circ_0072088 in esophageal squamous cell carcinoma (ESCC).
As a result, circ_0072088 was significantly overexpressed in ESCC tissues and cells, which was closely associated with tumor size, invasion depth, clinical stage, and lymph node metastasis of esophageal cancer.
Nuclear and cytoplasmic separation as well as FISH assays showed that circ_0072088 was mainly localized in the cytoplasm of ESCC cells.
RNase R treatment assay revealed that circ_0072088 was steadier than linear ZFR mRNA.
circ_0072088 promoted ESCC cell proliferation, migration and invasion in vitro, and cell proliferation in vivo.
Mechanistically, circ_0072088 upregulated VEGF gene expression by acting as the sponge of miRNA-377.
In conclusion, circ_0072088 might be used as a diagnostic biomarker and therapeutic target for ESCC.
American Psychological Association (APA)
Fang, Na& Shi, Yijun& Fan, Yu& Long, Tao& Shu, Yongqian& Zhou, Jianwei. 2020. Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377. Journal of Oncology،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1189162
Modern Language Association (MLA)
Fang, Na…[et al.]. Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377. Journal of Oncology No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1189162
American Medical Association (AMA)
Fang, Na& Shi, Yijun& Fan, Yu& Long, Tao& Shu, Yongqian& Zhou, Jianwei. Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1189162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189162