Impact of Commercialized Genomic Tests on Adjuvant Treatment Decisions in Early Stage Breast Cancer Patients
Joint Authors
Sbaity, Eman
Abdul Halim, Nour
Farhat, Fadi
Assi, Hazem I.
Alameh, Ibrahim A.
Khoury, Jessica
El Karak, Fadi
Berro, Juliett
Charafeddine, Maya
Salem, Ziad
El Saghir, Nagi
Tfayli, Arafat
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Advances in genomic techniques have been valuable in guiding decisions regarding the treatment of early breast cancer (EBC) patients.
These multigene assays include Oncotype DX, Prosigna, and Endopredict.
There has generally been a tendency to overtreat or undertreat patients, and having reliable prognostic factors could significantly improve rates of appropriate treatment administration.
In this study, we showcase the impact of genomic tests on adjuvant treatment decisions in EBC patients.
Materials and Methods.
This is a retrospective study that includes EBC patients treated between December 2016 and February 2018.
The physician’s choice of treatment was recorded before and after obtaining the results of the genomics tests.
Baseline demographics and pathological data were collected from medical records.
Results.
A total of 75 patients were included.
Fifty patients underwent Oncotype DX genomic analysis, 11 patients underwent Prosigna analysis, and 14 patients underwent Endopredict analysis.
A total of 21 physicians’ plans (28%) were initially undecided and then carried out after obtaining genomic test results.
13 patients were planned to undergo endocrine therapy alone, while 8 were planned to undergo both endocrine therapy and chemotherapy.
Treatment was changed in 26 patients (34.67%).
The decision to deescalate therapy was taken in 19 patients (25.33%).
The decision to escalate treatment was made in 7 patients (9.33%).
Conclusion.
Our study demonstrates the importance of genomics testing, as it assisted physicians in avoiding unnecessary adjuvant chemotherapy in 25.33% of patients, thus reducing side effects of chemotherapy and the financial burden on patients.
American Psychological Association (APA)
Assi, Hazem I.& Alameh, Ibrahim A.& Khoury, Jessica& Abdul Halim, Nour& El Karak, Fadi& Farhat, Fadi…[et al.]. 2020. Impact of Commercialized Genomic Tests on Adjuvant Treatment Decisions in Early Stage Breast Cancer Patients. Journal of Oncology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189177
Modern Language Association (MLA)
Assi, Hazem I.…[et al.]. Impact of Commercialized Genomic Tests on Adjuvant Treatment Decisions in Early Stage Breast Cancer Patients. Journal of Oncology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189177
American Medical Association (AMA)
Assi, Hazem I.& Alameh, Ibrahim A.& Khoury, Jessica& Abdul Halim, Nour& El Karak, Fadi& Farhat, Fadi…[et al.]. Impact of Commercialized Genomic Tests on Adjuvant Treatment Decisions in Early Stage Breast Cancer Patients. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189177