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Signal Transduction Pathways in Breast Cancer: The Important Role of PI3KAktmTOR
Joint Authors
Ortega, Miguel A
Asúnsolo, Ángel
Coca, Santiago
Buján, Julia
García-Honduvilla, Natalio
Fraile-Martínez, Oscar
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Breast cancer is the cancer with the highest prevalence in women and is the number-one cause of cancer mortality worldwide.
Cell transduction is a fundamental process in the development and progression of cancer.
Modifications in various cell signalling pathways promote tumour cell proliferation, progression, and survival.
The PI3K/Akt/mTOR pathway is an example of that, and it is involved in growth, proliferation, survival, motility, metabolism, and immune response regulation.
Activation of this pathway is one of the main causes of cancer cell resistance to antitumour therapies.
This makes PI3K/Akt/mTOR signalling a crucial object of study for understanding the development and progression of this disease.
Thus, this pathway may have a role as a potential therapeutic target, as well as prognostic and diagnostic value, in patients with breast cancer.
Despite the existence of selective PI3K/Akt/mTOR pathway inhibitors and current clinical trials, the cellular mechanisms are not yet known.
The present review aims to understand the current state of this important disease and the paths that must be forged.
American Psychological Association (APA)
Ortega, Miguel A& Fraile-Martínez, Oscar& Asúnsolo, Ángel& Buján, Julia& García-Honduvilla, Natalio& Coca, Santiago. 2020. Signal Transduction Pathways in Breast Cancer: The Important Role of PI3KAktmTOR. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189181
Modern Language Association (MLA)
Ortega, Miguel A…[et al.]. Signal Transduction Pathways in Breast Cancer: The Important Role of PI3KAktmTOR. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189181
American Medical Association (AMA)
Ortega, Miguel A& Fraile-Martínez, Oscar& Asúnsolo, Ángel& Buján, Julia& García-Honduvilla, Natalio& Coca, Santiago. Signal Transduction Pathways in Breast Cancer: The Important Role of PI3KAktmTOR. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189181