Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma
Joint Authors
Horii, Akira
Abe, Takahiro
Hoshi, Kazuto
Komatsu, Noriko
Komatsu, Miku
Ohashi, Riuko
Takato, Tsuyoshi
Hamakubo, Takao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide.
The standard treatment of surgery, chemotherapy, and radiotherapy can result in long-term complications which lower the patient’s quality of life, such as eating disorders, speech problems, and disfiguring or otherwise untoward cosmetic issues.
Antibody therapy against cancer-specific antigens is advantageous in terms of its lesser side effects achieved by its greater specificity, though the antitumor activity is still usually not enough to obtain a complete cure.
Robo1, an axon guidance receptor, has received considerable attention as a possible drug target in various cancers.
We have shown previously the enhanced cytotoxic effects of saporin-conjugated anti-Robo1 immunotoxin (IT-Robo1) on the HNSCC cell line HSQ-89 in combination with a photochemical internalization technique.
Considering the light source, which has only limited tissue penetrance, we examined the drug internalization effect of saponin.
Treatment with saponin facilitated significant cytotoxic effects of IT-Robo1 on HSQ-89 cells.
Saponin exerts its own nonspecific cytotoxicity, which may cover the actual extent of the internalization effect.
We thus examined whether a flashed treatment with saponin exerted a significant specific cytotoxic effect on cancer cells.
The combination of an immunotoxin with saponin also exhibited a significant tumor-suppressive effect on mice HSQ-19 xenografts.
These results suggest the utility of saponin treatment as an enhancer of immunotoxin treatment in cancer.
American Psychological Association (APA)
Komatsu, Noriko& Komatsu, Miku& Ohashi, Riuko& Horii, Akira& Hoshi, Kazuto& Takato, Tsuyoshi…[et al.]. 2020. Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma. Journal of Oncology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189197
Modern Language Association (MLA)
Komatsu, Noriko…[et al.]. Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma. Journal of Oncology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189197
American Medical Association (AMA)
Komatsu, Noriko& Komatsu, Miku& Ohashi, Riuko& Horii, Akira& Hoshi, Kazuto& Takato, Tsuyoshi…[et al.]. Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189197