The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis
Joint Authors
Xu, Wanying
Pepper, Dominique
Sun, Junfeng
Welsh, Judith
Cui, Xizhong
Eichacker, Peter Q.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Clinical studies suggest obesity paradoxically increases survival during bacterial infection and sepsis but decreases it with influenza, but these studies are observational.
By contrast, animal studies of obesity in infection can prospectively compare obese versus nonobese controls.
We performed a systematic review and meta-analysis of animal investigations to further examine obesity’s survival effect in infection and sepsis.
Methods.
Databases were searched for studies comparing survival in obese versus nonobese animals following bacteria, lipopolysaccharide, or influenza virus challenges.
Results.
Twenty-one studies (761 obese and 603 control animals) met the inclusion criteria.
Obesity reduced survival in 19 studies (11 significantly) and the odds ratio (95% CI) of survival (0.21(0.13, 0.35); I2 = 64%, p<0.01p < 0.01) but with high heterogeneity.
Obesity reduced survival (1) consistently in both single-strain bacteria- and lipopolysaccharide-challenged studies (n = 6 studies, 0.21(0.13, 0.34); I2 = 31%, p=0.20 and n = 5, 0.22(0.13, 0.36); I2 = 0%, p=0.59, respectively), (2) not significantly with cecal ligation and puncture (n = 4, 0.72(0.08, 6.23); I2 = 75%, p<0.01), and (3) significantly with influenza but with high heterogeneity (n = 6, 0.12(0.04, 0.34); I2 = 73%, p<0.01).
Obesity’s survival effects did not differ significantly comparing the four challenge types (p=0.49).
Animal models did not include antimicrobials or glycemic control and study quality was low.
Conclusions.
Preclinical and clinical studies together emphasize the need for prospective studies in patients accurately assessing obesity’s impact on survival during severe infection.
American Psychological Association (APA)
Xu, Wanying& Pepper, Dominique& Sun, Junfeng& Welsh, Judith& Cui, Xizhong& Eichacker, Peter Q.. 2020. The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis. Journal of Obesity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189213
Modern Language Association (MLA)
Xu, Wanying…[et al.]. The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis. Journal of Obesity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1189213
American Medical Association (AMA)
Xu, Wanying& Pepper, Dominique& Sun, Junfeng& Welsh, Judith& Cui, Xizhong& Eichacker, Peter Q.. The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis. Journal of Obesity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189213