Lipid-Induced Mechanisms of Metabolic Syndrome
Joint Authors
Novgorodtseva, Tatyana P.
Antonyuk, Marina V.
Denisenko, Yulia K.
Kytikova, Oxana Yu
Gvozdenko, Tatyana A.
Kantur, Tatyana A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology.
Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity.
In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators.
On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation.
On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS.
Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease.
The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.
American Psychological Association (APA)
Denisenko, Yulia K.& Kytikova, Oxana Yu& Novgorodtseva, Tatyana P.& Antonyuk, Marina V.& Gvozdenko, Tatyana A.& Kantur, Tatyana A.. 2020. Lipid-Induced Mechanisms of Metabolic Syndrome. Journal of Obesity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1189250
Modern Language Association (MLA)
Denisenko, Yulia K.…[et al.]. Lipid-Induced Mechanisms of Metabolic Syndrome. Journal of Obesity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1189250
American Medical Association (AMA)
Denisenko, Yulia K.& Kytikova, Oxana Yu& Novgorodtseva, Tatyana P.& Antonyuk, Marina V.& Gvozdenko, Tatyana A.& Kantur, Tatyana A.. Lipid-Induced Mechanisms of Metabolic Syndrome. Journal of Obesity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1189250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189250