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Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION)
Joint Authors
Yi, Zuohuizi
Chen, Liao
Wang, Xiaoling
Chen, Changzheng
Xing, Yiqiao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
We sought to explore the effects of intravitreal injection of the Rho-kinase inhibitor Y-27632 in a rodent model of nonarteritic anterior ischemic optic neuropathy (rAION).
Methods.
The rAION model was established by using laser-induced photoactivation of intravenously administered Rose Bengal in rats.
The rats received intravitreal injections of Y-27632 or PBS 1, 3, and 6 days after rAION induction.
Optical coherence tomography (OCT) was performed at 2 days and 4 weeks after induction.
Visual evoked potential (VEP) was used to evaluate the visual function at 4 weeks.
Brn3a immunofluorescence staining of surviving RGCs and apoptosis assays of RGCs were performed at 4 weeks.
Results.
Optic nerve head (ONH) width was significantly reduced in the Y-27632 group compared with that in the PBS group at 2 days after induction (p<0.05).
At 4 weeks, the P1 amplitude of flash-VEP (FVEP) in the Y-27632 group was significantly higher than that of the PBS group (p<0.05).
The RGC densities in the central and midperipheral retinas in the Y-27632 group were significantly higher than those in the PBS group (p<0.05).
Furthermore, there was a significant decrease in apoptotic RGCs in the Y-27632 group than in the PBS group (p<0.05).
Conclusions.
Intravitreal injection of Y-27632 had neuroprotective effects on ONH edema, RGC survival, and visual function preservation in rAION.
American Psychological Association (APA)
Yi, Zuohuizi& Chen, Liao& Wang, Xiaoling& Chen, Changzheng& Xing, Yiqiao. 2020. Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION). Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189293
Modern Language Association (MLA)
Yi, Zuohuizi…[et al.]. Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION). Journal of Ophthalmology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189293
American Medical Association (AMA)
Yi, Zuohuizi& Chen, Liao& Wang, Xiaoling& Chen, Changzheng& Xing, Yiqiao. Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION). Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189293