Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women
Joint Authors
Ephraim, Richard K. D.
Asiedu, Kofi
Kyei, Samuel
Animful, Stephen
Adanusa, Madison
Ali-Baya, Stephen Karim
Akorsah, Belinda
Sekyere, Mabel Antwiwaa
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To explore the relationship between serum prolactin, testosterone level, and tear film parameters.
The potential impact of these hormones on the health of the ocular surface in pregnant women was evaluated.
Methods.
This was a hospital-based cross-sectional study in which ocular symptoms (Ocular Surface Disease Index (OSDI)), tear function (fluorescein tear breakup time, Schirmer’s test 1), corneal and conjunctival staining, meibomian gland (MG) expressibility, and quality of secretion were measured.
Lid margin findings including lid notching, thickness, and lid margin telangiectasia were also recorded.
Venous blood was collected and the serum concentrations of prolactin and testosterone were determined using ELISA kits.
Correlation and multiple linear regression analyses were used to examine predictors of dry eye symptoms and signs.
Results.
A total of 160 pregnant women participated in the study and their mean age was 30.1 ± 4.6 years (range 18–42 years).
The correlation analysis indicated that testosterone concentration did not significantly correlate with any of the clinical parameters hence it was not included in the linear regression analysis.
However, prolactin serum concentration correlated significantly with Schirmer’s test 1.
Multiple linear regression was done to predict participants’ Schirmer’s test 1 score based upon their ocular surface staining score (oxford grading scale), meibomian gland expressibility, meibomian secretion quality, and serum concentration of prolactin.
Only predictors that significantly correlated with Schirmer’s test 1 in the correlation analysis were included in the linear regression analysis.
A significant regression equation was obtained (F (2, 157) = 5.119, p=0.007) with an R square of 0.05.
Multiple linear regression analysis revealed that concentration of prolactin (ß coefficient = 0.032, p=0.044) and meibomian gland expressibility scores (ß coefficient = 2.14, p=0.016) were associated with Schirmer’s test 1 scores when adjusted for duration of pregnancy.
Conclusion.
The study showed that increased serum prolactin levels have a weak but positive impact on Schirmer’s test 1 scores whilst serum testosterone level has no association with the clinical parameters of dry eye in pregnant women.
American Psychological Association (APA)
Kyei, Samuel& Ephraim, Richard K. D.& Animful, Stephen& Adanusa, Madison& Ali-Baya, Stephen Karim& Akorsah, Belinda…[et al.]. 2020. Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189295
Modern Language Association (MLA)
Kyei, Samuel…[et al.]. Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women. Journal of Ophthalmology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189295
American Medical Association (AMA)
Kyei, Samuel& Ephraim, Richard K. D.& Animful, Stephen& Adanusa, Madison& Ali-Baya, Stephen Karim& Akorsah, Belinda…[et al.]. Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189295