Incidence of Keratoconus and Its Association with Systemic Comorbid Conditions: A Nationwide Cohort Study from South Korea
Joint Authors
Park, Eun-Cheol
Moon, Jong Youn
Lee, Jesang
Park, Yoon Hyung
Lee, Si Hyung
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To determine the incidence of keratoconus and to determine its possible association with common systemic diseases using a nationwide cohort.
Methods.
This retrospective nationwide cohort study included 1,025,340 subjects from the Korean National Health Insurance Service-National Sample Cohort database from 2004 to 2013.
Estimates for incidence rates of keratoconus were identified.
After 1 : 5 matching using propensity scores, associations between keratoconus and certain systemic comorbidities were determined using multivariate logistic regression analysis.
Results.
The incidence during the same period was 15.1 cases per 100,000 person-years.
Adjusted logistic regression analysis after propensity score matching revealed significant associations between keratoconus and allergic rhinitis (odds ratio (OR): 1.86; 95% confidence interval (CI): 1.63–2.13; p<0.001), asthma (OR: 1.20; 95% CI: 1.06–1.36; p<0.001), atopic dermatitis (OR: 1.33; 95% CI: 1.13–1.56; p<0.001), and diabetes mellitus (DM) (OR: 1.35; 95% CI: 1.15–1.58; p<0.001).
Conclusion.
Estimates of the incidence of keratoconus may help in the planning of eye-care policies, and the results of this study determined the associations between allergic diseases and keratoconus.
Conflicting results regarding the association between keratoconus and DM should be further evaluated.
American Psychological Association (APA)
Moon, Jong Youn& Lee, Jesang& Park, Yoon Hyung& Park, Eun-Cheol& Lee, Si Hyung. 2020. Incidence of Keratoconus and Its Association with Systemic Comorbid Conditions: A Nationwide Cohort Study from South Korea. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189354
Modern Language Association (MLA)
Moon, Jong Youn…[et al.]. Incidence of Keratoconus and Its Association with Systemic Comorbid Conditions: A Nationwide Cohort Study from South Korea. Journal of Ophthalmology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1189354
American Medical Association (AMA)
Moon, Jong Youn& Lee, Jesang& Park, Yoon Hyung& Park, Eun-Cheol& Lee, Si Hyung. Incidence of Keratoconus and Its Association with Systemic Comorbid Conditions: A Nationwide Cohort Study from South Korea. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189354