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Electrophysiological and Structural Changes in Chinese Patients with LHON
Joint Authors
Li, Shiying
Liu, Yong
Robson, Anthony G.
Meng, Xiaohong
Guo, Hong
Yin, Zhengqin
Wang, Min
Wang, Gang
Long, Yanling
Liu, Bo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To review retrospectively the electrophysiological and structural changes in 13 Chinese patients with Leber hereditary optic neuropathy (LHON).
Methods.
26 eyes of 13 patients with a genetically confirmed diagnosis of LHON were categorized into two groups according to the duration of the disease: group 1 (duration less than 3 months) and group 2 (duration between 3 months and 18 years).
Clinical history, comprehensive visual electrophysiology, optical coherence tomography (OCT), and color fundus photography were performed.
Results.
Fundoscopy showed optic disc hyperemia in group 1 and optic atrophy in group 2.
OCT measures of retinal nerve fiber layer (RNFL) thickness around the optic disc and surrounding macula were normal in group 1 but reduced in group 2 (10 of 10 eyes).
The thickness of the retinal ganglion cell layer (GCL) plus inner plexiform layer (IPL) surrounding the macula reduced significantly in group 1 and group 2 compared with a healthy control group.
Pattern ERG (PERG) P50 amplitude was normal, but the N95/P50 ratio reduced in most of group 1 (4 of 5 eyes) and in all of group 2 (11 eyes).
PERG P50 peak time was abnormally short in group 2.
Multifocal electroretinography (mfERG) showed subnormal responses associated with ring 1 (the central area) and ring 2 in group 1 and reductions in rings 1, 2, and 3 in group 2.
Conclusion.
The study highlights differences in retinal structure and function between the acute and chronic stages of LHON in a group of Chinese patients.
There is PERG evidence of retinal ganglion cell dysfunction and OCT evidence of GCL + IPL thinning in both groups, but there is additional peripapillary RNFL loss in the chronic stage, associated with more severe RGC dysfunction.
There is multifocal ERG evidence of localized macular dysfunction in both acute and chronic groups.
The study highlights the importance of comprehensive electrophysiological and structural assessments of the retina in LHON and is pertinent to studies that aim to monitor disease progression or the effects of future therapeutic interventions.
American Psychological Association (APA)
Wang, Min& Guo, Hong& Li, Shiying& Wang, Gang& Long, Yanling& Meng, Xiaohong…[et al.]. 2020. Electrophysiological and Structural Changes in Chinese Patients with LHON. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189409
Modern Language Association (MLA)
Wang, Min…[et al.]. Electrophysiological and Structural Changes in Chinese Patients with LHON. Journal of Ophthalmology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189409
American Medical Association (AMA)
Wang, Min& Guo, Hong& Li, Shiying& Wang, Gang& Long, Yanling& Meng, Xiaohong…[et al.]. Electrophysiological and Structural Changes in Chinese Patients with LHON. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189409