Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects

Joint Authors

Wang, Dabo
Geng, Wenhui
Han, Jing

Source

Journal of Ophthalmology

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-04-13

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Purpose.

To explore the disease progression of primary open-angle glaucoma (POAG) in individuals with different degrees of VF defects by analyzing the trends in retinal nerve fiber layer (RNFL) changes at each stage.

Methods.

A total of 39 patients (77 eyes) were divided into three groups based on the severity of glaucomatous visual field (VF) loss: the first group included patients with mild baseline VF defects (mild group; n = 21 eyes).

The second group included patients with moderate VF defects (moderate group; n = 18 eyes).

The third group included patients with severe baseline VF defects (severe group; n = 38 eyes).

For all patients, slit-lamp biomicroscopy of the anterior and posterior segments and detailed fundus and optic disc inspections were performed, the intraocular pressure (IOP) was measured by Goldman tonometry, best-corrected visual acuity (BCVA) was measured, the RNFL thickness was measured by OCT, and the VF was assessed by the Octopus perimeter.

All the groups were followed up postoperatively for 18 months.

Results.

The mean RNFL thickness was recorded for all the visits.

Using simple linear regression analysis, we found that the R2 values of the three groups were 0.988, 0.982, and 0.814, respectively, and the slopes of mean RNFL thickness changes for mild, moderate, and severe baseline VF defects were −0.088, −0.082, and −0.015, respectively.

Moreover, we used simple linear regression analysis to explore whether and how the speed of RNFL thinning differs across groups.

The R2 values of the three groups were 0.982, 0.978, and 0.805, respectively, and the slopes for mild, moderate, and severe baseline VF defects were 0.089, 0.085, and 0.017, respectively.

Conclusion.

The rate of RNFL thinning is linear; RNFL thinning is the fastest in individuals with mild baseline VF defects, followed by those with moderate baseline VF defects.

In individuals with severe VF defects, changes in the RNFL thickness do not appropriately reflect the progression of the disease.

The clinical trial is registered with ChiCTR2000028975.

American Psychological Association (APA)

Geng, Wenhui& Wang, Dabo& Han, Jing. 2020. Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189430

Modern Language Association (MLA)

Geng, Wenhui…[et al.]. Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects. Journal of Ophthalmology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1189430

American Medical Association (AMA)

Geng, Wenhui& Wang, Dabo& Han, Jing. Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189430

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1189430