Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography
Joint Authors
Dai, Hong
Lu, Yingyi
Huang, Jianfeng
Zheng, Bodi
Gu, Xiaoya
Chen, Tong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
To quantify the capillary density of the optic nerve head in healthy control eyes and different stages of diabetic retinopathy (DR) eyes and identify the parameters to detect eyes with or without DR using optical coherence tomographic angiography (OCTA).
Methods.
In this cross-sectional study, 211 eyes of 121 participants with type 2 diabetes with different stages of DR or without DR and 73 eyes of 38 healthy age-matched controls were imaged by OCTA.
Radial peripapillary capillary (RPC) plexus density and retinal nerve fiber layer (RNFL) thickness were examined.
The mixed model binary logistic regression model was used to identify the parameters to detect eyes with or without DR.
The area under the receiver operating characteristic (ROC) curve was calculated.
Results.
RPC density decreased significantly in diabetic patients without DR compared with the healthy controls, and it was negatively correlated with the severity of DR (P<0.01).
RPC density was a significant parameter to distinguish diabetic eyes with or without DR (P<0.01).
The area under the ROC curve was 0.743.
Conclusions.
Quantification of RPC density by OCTA provides evidence of microvascular changes in the optic nerve in diabetic patients.
RPC density can serve as a possible biomarker in detecting eyes with DR.
Larger cohort studies need to support this statement.
American Psychological Association (APA)
Huang, Jianfeng& Zheng, Bodi& Lu, Yingyi& Gu, Xiaoya& Dai, Hong& Chen, Tong. 2020. Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1189449
Modern Language Association (MLA)
Huang, Jianfeng…[et al.]. Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography. Journal of Ophthalmology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1189449
American Medical Association (AMA)
Huang, Jianfeng& Zheng, Bodi& Lu, Yingyi& Gu, Xiaoya& Dai, Hong& Chen, Tong. Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1189449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189449