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Safety, Efficacy, and Predictive Factors of Conventional Epithelium-Off Corneal Crosslinking in the Treatment of Progressive Keratoconus
Joint Authors
Azar, Georges
Sahyoun, Marwan
Farhat, Rebecca
Ghannam, Mohamad Khaled
Nehme, Joseph
Hanna, Najib Georges
Abi Karam, Mariana
El Haber, Charbel
Schakal, Alexandre
Jalkh, Alexandre
Samaha, Ameed
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To report predictive factors of outcome of conventional epithelium-off corneal crosslinking (CXL) in the treatment of progressive keratoconus.
Methods.
This is a monocentric observational retrospective study conducted at Eye and Ear International Hospital, Lebanon.
All patients with progressive keratoconus who underwent CXL between January 2008 and January 2016, with minimal 3-years follow-up were included.
Primary treatment outcomes were maximum keratometry (K max), best-corrected distance visual acuity (CDVA), and failure.
Failure was defined as an increase of 1.00 diopters (D) or more in K max and/or an increase of 0.1 logMAR or more in CDVA and conversion to corneal transplantation.
Statistical analysis was done to identify predictors of treatment success.
Univariate and multivariate analyses were performed to determine the correlations between baseline parameters and outcomes, and an equation for predicting K max and CDVA was created.
Results.
156 eyes of 102 patients were enrolled.
The mean age was 23.85 ± 6.52 years.
Failure occurred in 31 eyes (19.87%).
Gender and thinnest pachymetry did not have any impact on postoperative outcomes.
Concerning the CDVA outcome, multivariate analysis showed that a better preoperative CDVA was associated with higher improvement in CDVA, and higher baseline K max and higher posterior mean K were associated with a worse outcome CDVA.
Regarding postoperative K max, a higher baseline K max, a worse baseline CDVA, and a younger age were associated with less flattening postoperatively.
Conclusion.
CXL is a safe and effective method in treating progressive keratoconus.
However, the clinical benefits can differ among patients, and in our series, a nonnegligible number of cases show a continued progression of their ectasia.
Further studies to identify predictors of postoperative progression prior to the procedure could help sort out good responders to treatment.
American Psychological Association (APA)
Farhat, Rebecca& Ghannam, Mohamad Khaled& Azar, Georges& Nehme, Joseph& Sahyoun, Marwan& Hanna, Najib Georges…[et al.]. 2020. Safety, Efficacy, and Predictive Factors of Conventional Epithelium-Off Corneal Crosslinking in the Treatment of Progressive Keratoconus. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189663
Modern Language Association (MLA)
Farhat, Rebecca…[et al.]. Safety, Efficacy, and Predictive Factors of Conventional Epithelium-Off Corneal Crosslinking in the Treatment of Progressive Keratoconus. Journal of Ophthalmology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189663
American Medical Association (AMA)
Farhat, Rebecca& Ghannam, Mohamad Khaled& Azar, Georges& Nehme, Joseph& Sahyoun, Marwan& Hanna, Najib Georges…[et al.]. Safety, Efficacy, and Predictive Factors of Conventional Epithelium-Off Corneal Crosslinking in the Treatment of Progressive Keratoconus. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189663