Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center
Joint Authors
Knier, Catherine G.
Fleischman, David
Hodge, David O.
Berdahl, John P.
Fautsch, Michael P.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Elevated intraocular pressure (IOP) is the most prevalent risk factor for primary open-angle glaucoma.
However, IOP alone does not fully describe a mechanical basis for disease in patients with normal tension glaucoma or primary open-angle glaucoma.
The translaminar pressure difference (TLPD) theory proposes that the pressure gradient generated by the difference of IOP and cerebrospinal fluid pressure (CSFp) acting at the level of the optic nerve can lead to cupping and glaucoma when IOP is higher than normal and/or CSFp is lower than normal.
The study results to date have generally supported the TLPD theory; however, varying methods, populations, and sample sizes make it difficult to compare results.
To further assess whether there is an association between low CSFp and open-angle glaucoma, 30 years of clinical data that assess 96,543 lumbar punctures were analyzed.
Patients with open-angle glaucoma showed a significantly lower CSFp than randomly selected normal control patients (9.9 ± 3 mm·Hg (n = 86) versus 12.1 ± 3.6 mm·Hg (n = 114), p<0.001) following adjustment for age and sex.
This retrospective study provides strong evidence for an association between open-angle glaucoma and low CSFp.
American Psychological Association (APA)
Knier, Catherine G.& Fleischman, David& Hodge, David O.& Berdahl, John P.& Fautsch, Michael P.. 2020. Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189666
Modern Language Association (MLA)
Knier, Catherine G.…[et al.]. Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center. Journal of Ophthalmology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189666
American Medical Association (AMA)
Knier, Catherine G.& Fleischman, David& Hodge, David O.& Berdahl, John P.& Fautsch, Michael P.. Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189666