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Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients
Joint Authors
Peto, Tunde
Ponto, Katharina
Lorenz, Katrin
Schuster, Alexander Karl-Georg
Pfeiffer, Norbert
Schulz, Andreas
Wild, Philipp S.
Lackner, Karl
Münzel, Thomas
Bell, Katharina
Beutgen, Vanessa M.
Nickels, Stefan
Scheller, Yvonne
Elbaz, Hisham
Schmidtmann, Irene
Grus, Franz H.
Beutel, M. E.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment.
In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular glaucoma (NVG), one of the major complications, is occurring within a 5-year timeframe.
Methods.
We performed a nested case-control study (1 : 4) within the Gutenberg Health Study (GHS), a population-based, prospective cohort study in the Rhine-Main Region of Germany including 15,010 participants.
RVO subjects (n = 59) were identified by grading of fundus photographs.
Optic nerves of RVO subjects and age- and sex-matched controls (n = 229) at baseline and their follow-up examination after 5 years were analyzed for glaucomatous alterations.
Of all RVO subjects and controls, serum autoantibody profiles were measured using in-house manufactured antigen-antibody microarrays.
Results.
Of the 59 RVO patients, 3 patients (5%) showed glaucomatous optic disc alterations at baseline, whereas no new glaucoma case was detected at 5-year follow-up.
Four of the autoantibodies measured (against dermcidin, neurotrophin-3, superoxide dismutase 1, and signal recognition particle 14 kDa protein) were significantly increased in the serum of RVO patients p<0.001.
Multivariable conditional logistic regression analysis showed that 3 of these 4 antibodies were independent of cardiovascular risk factors.
Conclusions.
We found several autoantibodies associated with RVO, targeting proteins and structures possibly involved in RVO pathogenesis.
American Psychological Association (APA)
Bell, Katharina& Beutgen, Vanessa M.& Nickels, Stefan& Lorenz, Katrin& Scheller, Yvonne& Elbaz, Hisham…[et al.]. 2020. Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189754
Modern Language Association (MLA)
Bell, Katharina…[et al.]. Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients. Journal of Ophthalmology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189754
American Medical Association (AMA)
Bell, Katharina& Beutgen, Vanessa M.& Nickels, Stefan& Lorenz, Katrin& Scheller, Yvonne& Elbaz, Hisham…[et al.]. Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189754