Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy
Joint Authors
Ansari-Shahrezaei, Siamak
Stattin, Martin
Daniel, Ahmed
Krepler, Katharina
Hagen, Stefan
Smretschnig, Eva
Frommlet, Florian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm2).
Methods.
Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350 μm (SW-350) and 1200 μm (SW-1200) diameter circle centered on the fovea and normalized with the level of SW-FAF GV in a 30° image of 20 eyes in 11 patients initially treated for unilateral acute symptomatic CSCR were collected and retrospectively analyzed after 7 years.
A 2-sided t-test was calculated to explore the differences of SW-350 and SW-1200 between one month and the long-term follow-up.
Results.
Mean differences (95% CI) in SW-FAF GV between 1 month and 7 years after half-fluence PDT were 0.07 ± 0.11 for SW-350 ([95% CI: −0.002; 0.14], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], p=0.03).
Mean differences in SW-FAF GV of the contralateral untreated eye were 0.06 ± 0.14 for SW-350 ([95% CI: −0.04; 0.17], p=0.22) and 0.05 ± 0.13 for SW-1200 ([95% CI: −0.04; 0.15], p=0.22).
Conclusion.
After 7 years, normalized SW-FAF GV were significantly lower in eyes with resolved acute CSCR treated with reduced-fluence PDT compared to the follow-up after 1 month without correlation to explicit pattern changes or structural damages.
Half-fluence PDT remains a safe and considerable treatment option in acute CSCR.
American Psychological Association (APA)
Stattin, Martin& Hagen, Stefan& Daniel, Ahmed& Smretschnig, Eva& Frommlet, Florian& Krepler, Katharina…[et al.]. 2020. Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189767
Modern Language Association (MLA)
Stattin, Martin…[et al.]. Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy. Journal of Ophthalmology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189767
American Medical Association (AMA)
Stattin, Martin& Hagen, Stefan& Daniel, Ahmed& Smretschnig, Eva& Frommlet, Florian& Krepler, Katharina…[et al.]. Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189767