Comparison between Cryopreserved and Dehydrated Human Amniotic Membrane Graft in Treating Challenging Cases with Macular Hole and Macular Hole Retinal Detachment
Joint Authors
Chen, Shih-Jen
Huang, Yu-Hsuan
Tsai, Der-Chong
Wang, Lei-Chi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To evaluate the surgical outcomes of cryopreserved and dehydrated human amniotic membrane (hAM) graft transplantation for macular hole (MH) and macular hole retinal detachment (MHRD) repair.
Materials and Methods.
This retrospective, interventional case series was conducted in two hospitals.
Two types of hAM grafts, namely, the dehydrated form (AmnioGen, HCT Regenerative, Taiwan) and the cryopreserved form (AmnioGraft, Bio-Tissue, Miami, FL), were consecutively used in MH surgeries.
Anatomical and functional outcomes between the 2 types of hAM grafts were compared.
Results.
Seventeen patients (mean age: 62.1 ± 10.0 years, 9 (52.9%) males) were enrolled.
Of them, 11 patients had persistent MH, 3 had MH without prior surgery, and 3 had MHRD.
A cryopreserved hAM graft was used in 10 patients, and a dehydrated hAM graft was used in 8 patients.
One patient used a cryopreserved hAM in the first MH surgery and a dehydrated hAM in the second surgery for extramacular hole with retinal detachment.
After a 6-month follow-up, 13 (76.5%) patients had sealed MHs.
The average visual acuity (VA) of cases with sealed MHs improved from 1.38 ± 0.62 to 1.12 ± 0.47 logMAR (p=0.03).
In the other 4 cases with persistent MH, 3 had graft dislocation and 1 had a reopened MH with graft contraction.
There were no significant differences in closure rate (80.00% vs.
71.43%, p=0.68) or VA improvement (0.19 ± 0.37 logMAR vs.
0.15 ± 0.41 logMAR, p=0.85) between the 2 kinds of hAM graft.
Conclusion.
This preliminary case series showed that both cryopreserved hAM and dehydrated hAM are feasible alternative grafts for either persistent or recurrent MH.
Both approaches have similar anatomical and functional outcomes.
American Psychological Association (APA)
Huang, Yu-Hsuan& Tsai, Der-Chong& Wang, Lei-Chi& Chen, Shih-Jen. 2020. Comparison between Cryopreserved and Dehydrated Human Amniotic Membrane Graft in Treating Challenging Cases with Macular Hole and Macular Hole Retinal Detachment. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189863
Modern Language Association (MLA)
Huang, Yu-Hsuan…[et al.]. Comparison between Cryopreserved and Dehydrated Human Amniotic Membrane Graft in Treating Challenging Cases with Macular Hole and Macular Hole Retinal Detachment. Journal of Ophthalmology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189863
American Medical Association (AMA)
Huang, Yu-Hsuan& Tsai, Der-Chong& Wang, Lei-Chi& Chen, Shih-Jen. Comparison between Cryopreserved and Dehydrated Human Amniotic Membrane Graft in Treating Challenging Cases with Macular Hole and Macular Hole Retinal Detachment. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189863