Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease
Joint Authors
Karaban, Irina
Povoroznyuk, Vladyslav
Bystrytska, Maryna
Grygorieva, Nataliia
Karasevich, Nina
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Osteoporosis and Parkinson’s disease (PD) are two important age-related diseases, which have an influence on pain, physical activity, disability, and mortality.
The aim of this research was to study the parameters of bone mineral density (BMD), frequency, and 10-year probability of osteoporotic fractures (OFs) in females with Parkinson’s disease (PD).
We have examined 113 postmenopausal women aged 50–74 years old which were divided into 2 groups (I, control group (CG), n = 53 and II, subjects with PD, n = 60).
Bone mineral density of lumbar spine, femoral neck, distal radius, and total body were measured, and quantity and localization of vertebral deformities were performed by the vertebral fracture assessment (VFA).
Ten-year probability of OFs was assessed by Ukrainian version of FRAX®.
It was established that BMD of lumbar spine, femoral neck, distal radius, and total body in PD women was reliably lower compared to CG.
The frequency of OFs in PD subjects was higher compared to CG (51.7 and 11.3%, respectively) with prevalence of vertebral fractures (VFs) in women with PD (52.6% among all fractures).
47.4% of the females had combined VFs: 74.2% of VFs were in thoracic part of the spine and 73.7% were wedge ones.
Ten-year probability of major OFs and hip fracture were higher in PD women compared to CG with and without BMD measurements.
Inclusion of PD in the FRAX calculation increased the requirement of antiosteoporotic treatment from 5 to 28% (without additional examination) and increased the need of additional BMD measurement from 50 to 68%.
Anterior/posterior vertebral height ratios (Th8-Th11) measured by VFA in PD females without confirmed vertebral deformities were lower compared to indices of CG.
In conclusion, women with PD have lower BMD indices, higher rate of osteoporosis, and risk of future low-energy fractures that should be taken into account in the assessment of their osteoporosis risk and clinical management.
American Psychological Association (APA)
Bystrytska, Maryna& Povoroznyuk, Vladyslav& Grygorieva, Nataliia& Karaban, Irina& Karasevich, Nina. 2020. Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease. Journal of Osteoporosis،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189933
Modern Language Association (MLA)
Bystrytska, Maryna…[et al.]. Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease. Journal of Osteoporosis No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189933
American Medical Association (AMA)
Bystrytska, Maryna& Povoroznyuk, Vladyslav& Grygorieva, Nataliia& Karaban, Irina& Karasevich, Nina. Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease. Journal of Osteoporosis. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189933