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A Reliable Method for Identification of Antibiotics by Terahertz Spectroscopy and SVM
Joint Authors
Guo, Jin
Deng, Hu
Liu, Quancheng
Chen, Linyu
Xiong, Zhonggang
Shang, Liping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Given the extensive use of antibiotics at present, the identification of antibiotics and production quality monitoring are of high importance.
However, conventional antibiotic identification methods have a low sensitivity and a long detection time.
Here, we propose an identification method that combines terahertz (THz) spectroscopy and chemometric technology.
THz time-domain spectroscopy (THz-TDS) was performed for sixteen types of antibiotics, including β-lactam, cephalosporins, macrolides, and tetracyclines.
The absorption spectra within the frequency range of 0.2–1.5 THz were calculated.
For dimensionality reduction, principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE) were implemented, respectively.
The data after dimensionality reduction were input into a support vector machine (SVM).
The model parameters were optimized through grid search (GS), genetic algorithm (GA), and particle swarm optimization (PSO) methods, and the optimal identification results were obtained after comparison across these methods.
Experiments indicate a differentiation of the THz absorption spectra among the sixteen types of antibiotics.
After dimensionality reduction, the training time of the model significantly decreased.
The use of the t-SNE-PSO-SVM model achieved the highest average accuracy on the prediction set, which was 99.91%.
Thus, our study does not only confirm that the t-SNE-PSO-SVM model proves to be a reliable method for antibiotics identification, but also confirms that the combination of THz-TDS and chemometric pattern recognition has great potential for drug detection.
American Psychological Association (APA)
Guo, Jin& Deng, Hu& Liu, Quancheng& Chen, Linyu& Xiong, Zhonggang& Shang, Liping. 2020. A Reliable Method for Identification of Antibiotics by Terahertz Spectroscopy and SVM. Journal of Spectroscopy،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190832
Modern Language Association (MLA)
Guo, Jin…[et al.]. A Reliable Method for Identification of Antibiotics by Terahertz Spectroscopy and SVM. Journal of Spectroscopy No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1190832
American Medical Association (AMA)
Guo, Jin& Deng, Hu& Liu, Quancheng& Chen, Linyu& Xiong, Zhonggang& Shang, Liping. A Reliable Method for Identification of Antibiotics by Terahertz Spectroscopy and SVM. Journal of Spectroscopy. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1190832