Discrimination of Melanoma Using Laser-Induced Breakdown Spectroscopy Conducted on Human Tissue Samples

Joint Authors

Wei, Kai
Teng, Geer
Khan, Muhammad Nouman
Wang, Qianqian
Idrees, Bushra Sana
Cui, Xutai

Source

Journal of Spectroscopy

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-30

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Physics

Abstract EN

Discrimination and identification of melanoma (a kind of skin cancer) by using laser-induced breakdown spectroscopy (LIBS) combined with chemometrics methods are reported.

The human melanoma and normal tissues are used in the form of formalin-fixed paraffin-embedded (FFPE) blocks as samples.

The results demonstrated higher LIBS signal intensities of phosphorus (P), potassium (K), sodium (Na), magnesium (Mg), and calcium (Ca) in melanoma FFPE samples while lower signal intensities in normal FFPE tissue samples.

Chemometric methods, artificial neural network (ANN), linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), and partial least square discriminant analysis (PLS-DA) are used to build the classification models.

Different preprocessing methods, standard normal variate (SNV), mean-centering, normalization by total area, and autoscaling, were compared.

A good performance of the model (sensitivity, specificity, and accuracy) for melanoma and normal FFPE tissues has been achieved by the ANN and PLS-DA models (all were 100%).

The results revealed that LIBS combined with chemometric methods for detection and discrimination of human malignancies is a reliable, accurate, and precise technique.

American Psychological Association (APA)

Khan, Muhammad Nouman& Wang, Qianqian& Idrees, Bushra Sana& Teng, Geer& Cui, Xutai& Wei, Kai. 2020. Discrimination of Melanoma Using Laser-Induced Breakdown Spectroscopy Conducted on Human Tissue Samples. Journal of Spectroscopy،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190839

Modern Language Association (MLA)

Wei, Kai…[et al.]. Discrimination of Melanoma Using Laser-Induced Breakdown Spectroscopy Conducted on Human Tissue Samples. Journal of Spectroscopy No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1190839

American Medical Association (AMA)

Khan, Muhammad Nouman& Wang, Qianqian& Idrees, Bushra Sana& Teng, Geer& Cui, Xutai& Wei, Kai. Discrimination of Melanoma Using Laser-Induced Breakdown Spectroscopy Conducted on Human Tissue Samples. Journal of Spectroscopy. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190839

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1190839