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A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
Joint Authors
Glávits, Róbert
Endres, John R.
Murbach, Timothy S.
Reddeman, Robin A.
Hirka, Gábor
Vértesi, Adél
Béres, Erzsébet
Szakonyiné, Ilona Pasics
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-04
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
A battery of OECD- and GLP-compliant toxicological studies was performed to assess the safety of a highly purified germanium sesquioxide, an organic form of the naturally occurring, nonessential trace element germanium.
Germanium dioxide and germanium lactate citrate (inorganic germaniums) have been shown to induce renal toxicity, whereas germanium sesquioxide (an organic germanium) has been shown to have a more favorable safety profile.
However, past toxicity studies on germanium sesquioxide compounds have not clearly stated the purity of the tested compounds.
In the studies reported herein, there was no evidence of mutagenicity in a bacterial reverse mutation test or an in vitro mammalian chromosomal aberration test.
There was no genotoxic activity observed in an in vivo mammalian micronucleus test at concentrations up to the limit dose of 2000 mg/kg bw/day.
In a 90-day repeated-dose oral toxicity study in Han:WIST rats conducted at doses of 0, 500, 1000, and 2000 mg/kg bw/day by gavage, there were no mortalities, treatment-related adverse effects, or target organs identified.
The no-observed-adverse-effect-level (NOAEL) was determined to be 2000 mg/kg bw/day.
American Psychological Association (APA)
Reddeman, Robin A.& Glávits, Róbert& Endres, John R.& Murbach, Timothy S.& Hirka, Gábor& Vértesi, Adél…[et al.]. 2020. A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium). Journal of Toxicology،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1190901
Modern Language Association (MLA)
Reddeman, Robin A.…[et al.]. A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium). Journal of Toxicology No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1190901
American Medical Association (AMA)
Reddeman, Robin A.& Glávits, Róbert& Endres, John R.& Murbach, Timothy S.& Hirka, Gábor& Vértesi, Adél…[et al.]. A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium). Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1190901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1190901