Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model
Joint Authors
Hassan, Ibrahim
Wan Ibrahim, Wan Norhamidah
Ahmad, Syahida
Yusuf, Ferdaus Mohamat
Ahmad, Siti Aqlima
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases.
Presently, treatment of these diseases is not effective and encounters many challenges due to the cost of drug and side effects.
Thus, the search for the alternative agents to replace synthetic drugs is in high demand.
Therefore, the aim of this study is to evaluate the anticholinesterase properties of Ginkgo biloba seed.
Methods.
The seed was extracted with 80% methanol.
Toxicity studies and evaluation of anticholinesterase activities were carried out in adult Javanese medaka (Oryzias javanicus).
Phytochemical study to identify the bioactive lead constituents of the crude extract was also carried out using high performance liquid chromatography (HPLC).
Results.
The result shows activities with high significant differences at P<0.001 between the treated and nontreated groups.
A bioactive compound (vitaxin) was identified with the aid of HPLC method.
Conclusion.
The presence of bioactive compound vitaxin is among the major secondary metabolites that contribute to increasing activities of this plant extract.
High anticholinesterase activities and low toxicity effect of this plant show its benefit to be used as natural medicine or supplements.
American Psychological Association (APA)
Hassan, Ibrahim& Wan Ibrahim, Wan Norhamidah& Yusuf, Ferdaus Mohamat& Ahmad, Siti Aqlima& Ahmad, Syahida. 2020. Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model. Journal of Toxicology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190917
Modern Language Association (MLA)
Hassan, Ibrahim…[et al.]. Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model. Journal of Toxicology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1190917
American Medical Association (AMA)
Hassan, Ibrahim& Wan Ibrahim, Wan Norhamidah& Yusuf, Ferdaus Mohamat& Ahmad, Siti Aqlima& Ahmad, Syahida. Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model. Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1190917