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The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo
Joint Authors
Tyshko, Nadezhda V.
Sadykova, Elvira O.
Shestakova, Svetlana I.
Nikitin, Nikolay S.
Trebukh, Marina D.
Loginova, Maria S.
Pashorina, Valentina A.
Zhminchenko, Valentin M.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The modeling of adaptation potential decrease in rats due to modification of the diet’s vitamin–mineral composition allows to increase animals’ sensitivity to toxic load in reprotoxicological experiments.
The threshold values of vitamins B1, B2, B3, and B6 and mineral substances Fe3+ and Mg2+ in the diet, which lead to a considerable reduction of laboratory animals’ adaptation potential, have been determined as 19% (from the basic level in the diet) for males and 18% for females.
The efficiency of this model has been confirmed in a reprotoxicological experiment with glyphosate as a toxic factor: the action of the toxic factor against the background of reduced availability of B vitamins and salts Fe3+ and Mg2+ led to significant changes in such indicators of reproductive function as mating efficiency, postimplantation loss, and the total number of alive pups, while the toxic effect of glyphosate was not so pronounced against the normal level of essential substances.
The obtained results prove that this adaptation potential reduction model can be recommended for the research of the low-toxicity objects reproductive toxicity in rats and for the safety assessment of novel food, in particular.
American Psychological Association (APA)
Tyshko, Nadezhda V.& Sadykova, Elvira O.& Shestakova, Svetlana I.& Nikitin, Nikolay S.& Trebukh, Marina D.& Loginova, Maria S.…[et al.]. 2020. The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo. Journal of Toxicology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1190925
Modern Language Association (MLA)
Tyshko, Nadezhda V.…[et al.]. The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo. Journal of Toxicology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1190925
American Medical Association (AMA)
Tyshko, Nadezhda V.& Sadykova, Elvira O.& Shestakova, Svetlana I.& Nikitin, Nikolay S.& Trebukh, Marina D.& Loginova, Maria S.…[et al.]. The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo. Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1190925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1190925