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Evaluating the Toxicity and Histological Effects of Al2O3 Nanoparticles on Bone Tissue in Animal Model: A Case-Control Study
Joint Authors
Soltaninejad, Hossein
Zare-Zardini, Hadi
Hamidieh, Amir Ali
Sobhan, Mohammad Reza
Saeed-Banadaky, Seyed Houssein
Amirkhani, Mohammad Amir
Tolueinia, Behnaz
Mehregan, Mohsen
Mirakhor, Mahnaz
Eshaghi, Farzaneh sadat
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The applications of nanostructures have been limited by their different toxicities.
So, the investigation of these toxicities is necessary before nanostructure application.
This study aimed to evaluate the effect of aluminum oxide (Al2O3) nanoparticles on bone density in Wistar rat.
Al2O3 nanoparticle was prepared by the sol-gel method.
Characterization was done by X-ray diffraction (XRD) and transmission electron microscopy (TEM).
Sixty-four male adult Wistar rats were divided into eight groups including six groups intravenously treated with Al2O3 nanoparticle at concentrations of 25, 50, 100, 250, 500, and 1000 µg/ml: one group received food and water as the control group, and one group received food and water as well as intravenously distilled water as an injection control group.
After 41 days, bone density was analyzed by dual-energy X-ray absorptiometry (DEXA).
According to X-ray diffraction, the average particle size for Al2O3 nanoparticles was 20.85 nm.
The data of densitometry showed that the bone density of right and left foot was reduced in concentrations of 250, 500, and 1000 µg/ml that were statistically significant in comparison with the control group.
The reduction of bone density was increased with the enhancement of nanostructures concentration.
The effect of Al2O3 nanoparticles on bone density was similar in the left and right legs.
Histopatholological assessment also showed that Al2O3 nanoparticles (250, 500, and 1000 µg/ml) lead to significant reduction of trabeculae.
Empty lacunae are observed in these three groups.
Considering that high concentrations of Al2O3 nanoparticles had toxicity on bone tissue, it must be used by more caution, especially its use as a coating in different devices such as implants, surgical instruments, and bone prostheses.
American Psychological Association (APA)
Soltaninejad, Hossein& Zare-Zardini, Hadi& Hamidieh, Amir Ali& Sobhan, Mohammad Reza& Saeed-Banadaky, Seyed Houssein& Amirkhani, Mohammad Amir…[et al.]. 2020. Evaluating the Toxicity and Histological Effects of Al2O3 Nanoparticles on Bone Tissue in Animal Model: A Case-Control Study. Journal of Toxicology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1190934
Modern Language Association (MLA)
Soltaninejad, Hossein…[et al.]. Evaluating the Toxicity and Histological Effects of Al2O3 Nanoparticles on Bone Tissue in Animal Model: A Case-Control Study. Journal of Toxicology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1190934
American Medical Association (AMA)
Soltaninejad, Hossein& Zare-Zardini, Hadi& Hamidieh, Amir Ali& Sobhan, Mohammad Reza& Saeed-Banadaky, Seyed Houssein& Amirkhani, Mohammad Amir…[et al.]. Evaluating the Toxicity and Histological Effects of Al2O3 Nanoparticles on Bone Tissue in Animal Model: A Case-Control Study. Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1190934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1190934