Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals
Joint Authors
Marques, Claudia Diniz Lopes
Duarte, Angela Luzia Branco Pinto
Brito, Carlos A. A. de
França, Rafael F. O.
Monteiro, Janaína R.
de Brito, Marina C. M.
Lopes, Fabiana
Lima, Anton
Marques, Gabriel L.
Valadares, Maria Luisa
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients.
This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls.
Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p=0.79).
Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively (p=0.87).
Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control group and only in 28% in the bDMARD group (p=0.021), maintaining a statistically significant difference only for users of anti-TNF.
This study found that patients affected by chikungunya fever using bDMARDs did not present severe forms or complications in the acute phase of the disease, and patients using anti-TNF biologicals had a lower frequency of chronic joint symptoms than the household controls.
This favorable outcome may be related to the cytokine blockade, with a reduction in the inflammatory response and joint damage.
American Psychological Association (APA)
Brito, Carlos A. A. de& Marques, Claudia Diniz Lopes& França, Rafael F. O.& Monteiro, Janaína R.& de Brito, Marina C. M.& Lopes, Fabiana…[et al.]. 2020. Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals. Journal of Tropical Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191252
Modern Language Association (MLA)
Brito, Carlos A. A. de…[et al.]. Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals. Journal of Tropical Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1191252
American Medical Association (AMA)
Brito, Carlos A. A. de& Marques, Claudia Diniz Lopes& França, Rafael F. O.& Monteiro, Janaína R.& de Brito, Marina C. M.& Lopes, Fabiana…[et al.]. Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals. Journal of Tropical Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191252