Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice
Joint Authors
Somsak, Voravuth
Ounjaijean, Sakaewan
Benjasak, Nattida
Sae-lao, Suchanan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Kaempferol (KMF) is a member of flavonol widely found in tea, broccoli, apples, strawberries, and beans.
It has been demonstrated to present several pharmacological properties with potent antimalarial activity against Plasmodium berghei-infected mice.
Hence, the search for a safe and new antimalarial compound with combinations to delay the development of resistance was the aim of this study.
Thus, the therapeutic effect of the combination of KMF and artesunate (ART) in P.
berghei-infected mice was evaluated.
Combination of KMF and ART in P.
berghei ANKA- (PbANKA-) infected ICR mice in a fixed-ratio combination (1 : 1) and fractions of their median effective dose (ED50) was also investigated using the standard 4-day suppressive test.
The ED50 levels of KMF and ART in mice infected with PbANKA were 20.06 ± 2.65 and 6.06 ± 1.33 mg/kg, respectively.
Moreover, KMF showed promising synergistic combination with ART at the doses of their ED50 and fixed-ratio combination (1 : 1) of their ED50 of 1/2 with combination index (CI) values of 0.86 and 0.47, respectively.
Additionally, KMF, ART, and its combination at the doses of their ED50 and fixed-ratio combination (1 : 1) of their ED50 of 1/2 also presented significantly (P<0.001) prolonged mean survival time (MST).
The findings of this study showed that a combination of KMF and ART enhanced the antimalarial activity of ART and prolonged MST.
This study supports the basis for the selection of KMF as a prospective compound for further consideration as a partner drug for ART.
American Psychological Association (APA)
Ounjaijean, Sakaewan& Benjasak, Nattida& Sae-lao, Suchanan& Somsak, Voravuth. 2020. Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice. Journal of Tropical Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1191316
Modern Language Association (MLA)
Ounjaijean, Sakaewan…[et al.]. Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice. Journal of Tropical Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1191316
American Medical Association (AMA)
Ounjaijean, Sakaewan& Benjasak, Nattida& Sae-lao, Suchanan& Somsak, Voravuth. Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice. Journal of Tropical Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1191316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191316