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Reduced Graphene Oxide Decorated with AuNPs as a New Aptamer-Based Biosensor for the Detection of Androgen Receptor from Prostate Cells
Joint Authors
Pedrosa, Valber A.
Crulhas, Bruno P.
Basso, Caroline R.
Parra, João P. R. L. L.
Castro, Gustavo R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Here we described an aptasensor based on graphene oxide (GO) decorated with gold nanoparticles (AuNPs) able to detect the AR released by prostate cells, in order to provide new insights about the relationship between AR and prostate cancer for a more precise diagnosis for cancer.
Characterization of the surface modified GE was carried out by cyclic voltammetry and electrochemical impedance spectroscopy using ferrocene as a redox probe.
Under the optimized experimental conditions, a detection limit of 0.5 ng/mL (3σ/slope) was obtained by the present electrochemical biosensor, along with a linear range of 0-110 ng/mL.
By virtue of excellent sensitivity, specificity, and repeatability, the present electrochemical biosensor provides a potential application in clinical diagnosis.
American Psychological Association (APA)
Crulhas, Bruno P.& Basso, Caroline R.& Parra, João P. R. L. L.& Castro, Gustavo R.& Pedrosa, Valber A.. 2019. Reduced Graphene Oxide Decorated with AuNPs as a New Aptamer-Based Biosensor for the Detection of Androgen Receptor from Prostate Cells. Journal of Sensors،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1191339
Modern Language Association (MLA)
Crulhas, Bruno P.…[et al.]. Reduced Graphene Oxide Decorated with AuNPs as a New Aptamer-Based Biosensor for the Detection of Androgen Receptor from Prostate Cells. Journal of Sensors No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1191339
American Medical Association (AMA)
Crulhas, Bruno P.& Basso, Caroline R.& Parra, João P. R. L. L.& Castro, Gustavo R.& Pedrosa, Valber A.. Reduced Graphene Oxide Decorated with AuNPs as a New Aptamer-Based Biosensor for the Detection of Androgen Receptor from Prostate Cells. Journal of Sensors. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1191339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191339