Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer
Joint Authors
Castells, Ignasi
Granada, Maria Luisa
Reverter, Jordi Lluis
Rosas-Allende, Irene
Puig-Jove, Carlos
Zafon, Carles
Megia, Ana
Pizarro, Eduarda
Puig-Domingo, Manel
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers.
Design and Methods.
We retrospectively studied 98 subjects (83 women, 47 ± 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any time during the follow-up.
Patients presented five different patterns of evolution of serum TgAb concentrations: (1) stable positive TgAb, (2) de novo appearance, (3) an increase of more than 50%, (4) TgAb levels from positive to negative, and (5) a decrease of more than 50%.
Results.
In the group of 11 patients with stable TgAb, four cases presented persistence of the disease with structural incomplete response.
In the group of 22 patients with sustained increasing trend rising more than 50% or de novo detectable TgAb levels, three patients were diagnosed with structural incomplete response.
There was no evidence of recurrence or persistence of the disease in any of the 65 patients who showed a significant decrease in (n = 35) or disappearance of (n = 30) TgAb.
Conclusions.
Our results suggest that not only the appearance of a significant increase in TgAb but also stable concentrations of TgAb should be regarded as a sufficient risk condition for an active search for recurrent or persistent disease.
Conversely, a significant decrease in TgAb levels can represent a good prognostic sign.
American Psychological Association (APA)
Reverter, Jordi Lluis& Rosas-Allende, Irene& Puig-Jove, Carlos& Zafon, Carles& Megia, Ana& Castells, Ignasi…[et al.]. 2020. Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer. Journal of Thyroid Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191388
Modern Language Association (MLA)
Reverter, Jordi Lluis…[et al.]. Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer. Journal of Thyroid Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1191388
American Medical Association (AMA)
Reverter, Jordi Lluis& Rosas-Allende, Irene& Puig-Jove, Carlos& Zafon, Carles& Megia, Ana& Castells, Ignasi…[et al.]. Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer. Journal of Thyroid Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191388