Sirtuin 1: A Dilemma in Transplantation
Joint Authors
Assadiasl, Sara
Mooney, Nuala
Mohebbi, Bahareh
Fatahi, Yousef
Soleimanifar, Narjes
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
In view of the anti-inflammatory properties of sirtuin 1 along with its protective role in ischemia reperfusion injury, it might be considered as contributing to the promotion of transplantation outcome.
However, the potential ability of sirtuin 1 to induce malignancies raises some concerns about its overexpression in clinic.
Moreover, despite the findings of sirtuin 1 implication in thymic tolerance induction and T regulatory (Treg) cells survival, there is also evidence for its involvement in Treg suppression and in T helper 17 cells differentiation.
The identification of sirtuin 1 natural and synthetic activators leads to the proposal of sirtuin 1 as an eligible target for clinical interventions in transplantation.
All positive and negative consequences of sirtuin 1 overactivation/overexpression in the allograft should therefore be studied thoroughly.
Herein, we summarize previous findings concerning direct and indirect influences of sirtuin 1 manipulation on transplantation.
American Psychological Association (APA)
Assadiasl, Sara& Mooney, Nuala& Mohebbi, Bahareh& Fatahi, Yousef& Soleimanifar, Narjes. 2020. Sirtuin 1: A Dilemma in Transplantation. Journal of Transplantation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191397
Modern Language Association (MLA)
Assadiasl, Sara…[et al.]. Sirtuin 1: A Dilemma in Transplantation. Journal of Transplantation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191397
American Medical Association (AMA)
Assadiasl, Sara& Mooney, Nuala& Mohebbi, Bahareh& Fatahi, Yousef& Soleimanifar, Narjes. Sirtuin 1: A Dilemma in Transplantation. Journal of Transplantation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191397