Risk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis
Joint Authors
Yao, Yu-xia
Cao, Bangwei
Su, Qiang
Zhang, Xiao-chen
Zhang, Chen-guang
Hou, Yan-li
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We performed a systematic review and meta-analysis to determine the risk of immune-related pancreatitis associated with the treatment by immune checkpoint inhibitors (ICIs) for solid tumors.
Eligible studies were selected from multiple databases including phase II/III randomized controlled trials (RCTs) with ICIs in solid tumor patients.
The data were analyzed with Stata version 12.0 software.
After excluding ineligible studies, a total of 15 clinical trials were considered eligible for the meta-analysis, which included 9099 patients.
Compared with chemotherapy or placebo, the risk ratio (RR) for all-grade lipase elevation after CTLA-4 inhibitor treatment was 1.05 (95% confidence interval (CI): 1.01–2.24, p=0.047).
However, the risk for pancreatitis after ICI treatment in any subgroup was not significantly higher than that after control therapy.
In addition, compared with ipilimumab/nivolumab alone, the RR for all-grade and high-grade lipase elevation under combination treatment of nivolumab and ipilimumab was 6.43 (95% CI: 1.43–28.99, p=0.015) and 6.44 (95% CI: 1.39–29.79, p=0.017), respectively, and the RR for all-grade amylase elevation under combination treatment was 6.08 (95% CI: 1.51–24.44, p=0.011).
Our meta-analysis has demonstrated that both CTLA-4 inhibitors alone and combination treatment of nivolumab and ipilimumab could increase the risk of amylase or lipase elevation, but not significantly increase the risk of pancreatitis when compared with controls.
American Psychological Association (APA)
Su, Qiang& Zhang, Xiao-chen& Zhang, Chen-guang& Hou, Yan-li& Yao, Yu-xia& Cao, Bangwei. 2018. Risk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1191521
Modern Language Association (MLA)
Su, Qiang…[et al.]. Risk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1191521
American Medical Association (AMA)
Su, Qiang& Zhang, Xiao-chen& Zhang, Chen-guang& Hou, Yan-li& Yao, Yu-xia& Cao, Bangwei. Risk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1191521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191521