Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome
Joint Authors
Kiripolsky, Jeremy
Kramer, Jill M.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
While the importance of Toll-like receptor (TLR) signaling is well established in many autoimmune diseases, the role of TLR activation in Sjögren’s syndrome (SS) is poorly understood.
Studies in mice and humans reveal that TLRs are potent mediators of inflammation in SS.
TLRs are expressed and functional in salivary tissue, and TLRs in peripheral blood cells of SS patients are also upregulated and hyperresponsive to ligation.
In this review, we will detail observations in mouse models regarding the importance of TLR activation in both local and systemic disease.
We will then discuss studies in SS patients that provide evidence of the importance of TLR-mediated signaling in disease.
While the ligands that activate TLRs in the context of SS are unknown, emerging data suggest that damage-associated molecular patterns (DAMPs) may be significant drivers of the chronic and unremitting inflammation that is characteristic of SS.
We will discuss putative DAMPs that may be of clinical significance in disease.
Therapies that target TLR signaling cascades will likely reduce both exocrine-specific and systemic manifestations of SS.
American Psychological Association (APA)
Kiripolsky, Jeremy& Kramer, Jill M.. 2018. Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1191546
Modern Language Association (MLA)
Kiripolsky, Jeremy& Kramer, Jill M.. Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1191546
American Medical Association (AMA)
Kiripolsky, Jeremy& Kramer, Jill M.. Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1191546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191546