Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome

Joint Authors

Kiripolsky, Jeremy
Kramer, Jill M.

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-12-20

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

While the importance of Toll-like receptor (TLR) signaling is well established in many autoimmune diseases, the role of TLR activation in Sjögren’s syndrome (SS) is poorly understood.

Studies in mice and humans reveal that TLRs are potent mediators of inflammation in SS.

TLRs are expressed and functional in salivary tissue, and TLRs in peripheral blood cells of SS patients are also upregulated and hyperresponsive to ligation.

In this review, we will detail observations in mouse models regarding the importance of TLR activation in both local and systemic disease.

We will then discuss studies in SS patients that provide evidence of the importance of TLR-mediated signaling in disease.

While the ligands that activate TLRs in the context of SS are unknown, emerging data suggest that damage-associated molecular patterns (DAMPs) may be significant drivers of the chronic and unremitting inflammation that is characteristic of SS.

We will discuss putative DAMPs that may be of clinical significance in disease.

Therapies that target TLR signaling cascades will likely reduce both exocrine-specific and systemic manifestations of SS.

American Psychological Association (APA)

Kiripolsky, Jeremy& Kramer, Jill M.. 2018. Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1191546

Modern Language Association (MLA)

Kiripolsky, Jeremy& Kramer, Jill M.. Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1191546

American Medical Association (AMA)

Kiripolsky, Jeremy& Kramer, Jill M.. Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1191546

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1191546