Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules.
One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant.
It also has anti-inflammatory, neuroprotective, and sympatholytic qualities.
The aim of this study was to establish whether DEX also offers protection against ischemia and reperfusion- (I/R-) induced AKI in rats.
An intraperitoneal injection of DEX (25 μg/kg) was administered 30 min prior to the induction of I/R.
The results indicate that in the I/R rats, DEX played a protective role by reducing the damage to the tubules and maintaining renal function.
Furthermore, in response to I/R, the DEX treatment reduced the mRNA expression of TNF-α, IL-1β, IL-6, and MCP-1 in the kidney tissues and the serum levels of TNF-α, IL-1β, IL-6, and MCP-1.
DEX also reduced the levels of oxidative stress and apoptosis in the tubular cells.
These results indicate that in response to I/R kidney injury, DEX plays a protective role by inhibiting inflammation and tubular cell apoptosis, reducing the production of reactive oxygen species, and promoting renal function.
American Psychological Association (APA)
Bao, Naren& Dai, Di. 2020. Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191565
Modern Language Association (MLA)
Bao, Naren& Dai, Di. Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191565
American Medical Association (AMA)
Bao, Naren& Dai, Di. Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191565